References

ldt

Лучевая диагностика и терапия

Diagnostic radiology and radiotherapy

2079-5343

Baltic Medical Education Center

10.22328/2079-5343-2016-1-82-94

ldt-114

Research Article

СТАНДАРТЫ ОКАЗАНИЯ МЕДИЦИНСКОЙ ПОМОЩИ

STANDARTS OF MEDICAL CARE

ПРИМЕНЕНИЕ МАГНИТНО-РЕЗОНАНСНЫХ КОНТРАСТНЫХ СРЕДСТВ В ДЕТСКОЙ ПРАКТИКЕ

USE OF CONTRAST-ENHANCED MAGNETIC RESONANCE IN PEDIATRIC PATIENTS

Алиханов

Алихан Амруллахович

Alihanov

A. A.

alikehan@mail.ru

Шимановский

Николай Львович

Shimanovsky

N. L.

noemail@neicon.ru

Российский национальный исследовательский медицинский университет им. Н. И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian Federation

2016

30032016

018294

2016

Алиханов А.А., Шимановский Н.Л.

Alihanov A.A., Shimanovsky N.L.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://radiag.bmoc-spb.ru/jour/article/view/114

Описаны современные достижения в применении МРТ с контрастным усилением в сравнении с другими методами лучевой диагностики у детей любого возраста. Даны рекомендации по выбору магнитно-резонансного контрастного средства и рассмотрены пути оптимизации его применения. Подчеркиваются безопасность макроциклических контрастных средств и высокая диагностическая эффективность препаратов с высокой релаксирующей способностью и двойной концентрацией гадолиния (Гадовист).

This article reviews recent developments in pediatric contrast-enhanced MRI and offers recommendations on current best practice. Gadolinium-based contrast media with high relaxivity and high concentration (Gadovist) are recommended for enhancing imaging quality. The choice of most appropriate contrast medium should be based on criteria of safety, tolerability, and efficacy, characterized in age-specific clinical trials and personal experience.

МРТконтрастное усилениегадобутролmagnetic resonance imagingcontrast-enhancedgadobutrol

References1

Brenner D. J. Estimating cancer risks from pediatric CT: going from the qualitative to the quantitative // Pediatr Radiol.- 2002.- Vol. 32(4).- P 228-231.

Brenner D. J., Elliston C. D., Hall E. J., Berdon W. E. Estimates of the cancer risks from pediatric CT radiation are not merely theoretical: comment on «point/counterpoint: in x-ray computed tomography, technique factors should be selected appropriate to patient size. Against the proposition» // Med Phys.- 2001.- Vol. 28 (11).- Р 2387-2388.

ACR practice guideline for the performance and interpretation of pediatric magnetic resonance imaging. American College of Radiology; [Accessed July 25, 2013]. http:// www.acr.org/~/me-dia/6DA1E94ED99645CDB414AB325414F542.pdf.

Bhargava R., Hahn G., Hirsch W. et al. Contrast-enhanced magnetic resonance imaging in pediatric patients: review and recommendations for current practice // Magn Reson Insights.- 2013.- Vol. 6.- Р. 95-111.

Balassy C., Hormann M. Role of MRI in paediatric musculoskeletal conditions // Eur. J. Radiol.- 2008.- Vol. 68 (2).- Р. 245-258.

Hormann M. MR imaging of the gastro-intestinal tract in children // Eur. J. Radiol.- 2008.- Vol. 68(2).- Р. 271-277.

Vezina L. G. Imaging of central nervous system tumors in children: advances and limitations // J. Child Neurol.- 2008.- Vol. 23 (10).- Р. 1128-1135.

Callen D. J. MRI in the diagnosis of pediatric multiple sclerosis./ D. J. Callen, M. M. Shroff, H. M. Branson, et al. Neurology.- 2009.- Vol. 72(11).- Р. 961-967.

Battal B. Diffusion-weighted MRI beyond the central nervous system in children. / B. Battal, V. Akgun, M. Kocaoglu// Diagn Interv Radiol.- 2012.- Vol. 18(3).- Р. 288-297.

Utsunomiya H. Diffusion MRI abnormalities in pediatric neurological disorders./ H.Utsunomiya // Brain Dev. - 2011.- Vol. 33(3).- Р. 235-242.

Aaen G. S. Magnetic resonance spectroscopy predicts outcomes for children with nonaccidental trauma. / G. S. Aaen, B. A. Holshouser, C. Sheridan et al. // Pediatrics.- 2010.- Vol. 125 (2).- Р. 295-303.

Cecil K.M. MR spectroscopy of metabolic disorders Neuroimaging // Clin N Am.- 2006.- Vol. 16(1).- Р. 87-116.

Thomas B., Al D. N., Widjaja E. MRI of childhood epilepsy due to inborn errors of metabolism // Am. J. Roentgenol.- 2010.- Vol. 194 (5).- Р W367-W374.

Chen J., Licht D. J., Smith S. E. et al. Arterial spin labeling perfusion MRI in pediatric arterial ischemic stroke: initial experiences // J. Magn. Reson. Imaging.- 2009.- Vol. 29(2).- Р 282-290.

Sancheëz C. E., Richards J. E., Almli C. R. Age-specific MRI templates for pediatric neuroimaging // Dev Neuropsychol.- 2012.- Vol. 37(5).- Р. 379-399.

Sanchez C. E., Richards J. E., Almli C. R. Neurodevelopmental MRI brain templates for children from 2 weeks to 4 years of age // Dev Psychobiol.- 2012.- Vol. 54 (1).- Р 77-91.

Bailliard F., Hughes M. L., Taylor A. M. Introduction to cardiac imaging in infants and children: techniques, potential, and role in the imaging work-up of various cardiac malformations and other pediatric heart conditions // Eur. J. Radiol.- 2008.- Vol. 68 (2).- Р 191-198.

Shenoy-Bhangle A., Nimkin K., Gee M. S. Pediatric imaging: current and emerging techniques // J. Postgrad Med.- 2010.- Vol. 56 (2).- Р 98-102.

Шимановский Н. Л., Наполов Ю. К. Применение магнитно-резонансной визуализации с контрастным усилением для диагностики заболеваний мочевыделительной системы. I. Диагностика морфологических и функциональных нарушений. Магнитно-резонансная ангиография почек // Урология.- 2006.- № 6.- С. 93-95.

MacKenzie J. D., Vasanawala S. S. State-of-the-art in pediatric body and musculoskeletal magnetic resonance imaging [abstract] // Semin Ultrasound CT MR.- 2010.- Vol. 31 (2).- Р 86-99.

Coté C. J., Wilson S. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update // Pediatrics.- 2006.- Vol. 118 (6).- Р. 2587-2602.

Schulte-Uentrop L., Goepfert M. S. Anaesthesia or sedation for MRI in children // Curr. Opin. Anaesthesiol.- 2010.- Vol. 23 (4).- Р 513-517.

Wachtel R. E., Dexter F., Dow A. J. Growth rates in pediatric diagnostic imaging and sedation // Anesth Analg.- 2009.- Vol. 108 (5).- Р 1616-1621.

Heng V. C., Bajard А., Thiesse Р. Deep sedation in pediatric imaging: efficacy and safety of intravenous chlorpromazine // Pediatr Radiol.- 2012.- Vol. 42(5).- Р 552-561.

Vasanawala S. S., Lustig М. Advances in pediatric body MRI // Pediatr Radiol.- 2011.- Vol. 41 (Suppl 2).- Р 549-554.

Alfke K. Contrast-enhanced magnetic resonance angiography in stroke diagnostics: additional information compared with time-of-flight magnetic resonance angiography? / K. Alfke, U. Jensen, C. Pool, et al. // Clin Neuroradiol.- 2011.- Vol. 21 (1).- Р 5-10.

Triulzi F Paediatric neuroimaging // Neurol Sci.- 2008.- Vol. 29 (Suppl 3).- Р 342-345.

Hirsch W., Sorge I., Krohmer S. et al. MRI of the lungs in children // Eur. J. Radiol.- 2008.- Vol. 68 (2) - P 278-288.

Olsen O. E. Practical body MRI-A paediatric perspective // Eur. J. Radiol.- 2008.- Vol. 68 (2).- Р 299-308.

Kunze C., Mentzel H. J., Krishnamurthy R. et al. Pharmacokinetics and Safety of Macrocyclic Gadobutrol in Children Aged Younger Than 2 Years Including Term Newborns in Comparison to Older Populations // Invest Radiol.- 2015.- Sep. 3.

Шимановский Н. Л. Контрастные средства. Руководство по рациональному применению // Сер. Библиотека врача-специалиста. Лучевая диагностика.- 2009.- C. 463.

Алиханов А. А., Шимановский Н. Л. Преимущества применения одномолярного гадолинийсодержащего магнитно-резонансного контрастного средства по сравнению с полумолярными препаратами при диагностике рассеянного склероза // Медицинская визуализация.- 2008.- № 5.- С. 73-80.

Mentzel H. J., Seidel I J., Fitzek C. et al. Pediatric brain MRI in neurofibromatosis type // Eur. Radiol.- 2005.- Vol. 15(4).- Р 814-822.

Nickerson J. P., Richner B., Santy K. et al. Neuroimaging of pediatric intracranial infection - part 1: techniques and bacterial infections // J. Neuroimaging.- 2012.- Vol. 22 (2).- Р e42-e51.

Mulkey S. B., Glasier C. M., El-Nabbout B. et al. Nerve root enhancement on spinal MRI in pediatric Guillain-Barré syndrome // Pediatr Neurol.- 2010.- Vol. 43(4).- Р 263-269.

Lobel U., Sedlacik J., Reddick W. E. et al. Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma // Am. J. Neuroradiol.- 2011.- Vol. 32(2).- Р 315-322.

Kan J., Young R., Yu C., Hernanz-Schulman M. Clinical impact of gadolinium in the MRI diagnosis of musculoskeletal infection in children // Pediatr Radiol.- 2010.- Vol. 40 (7).- Р 1197-1205.

Grattan-Smith J. D., Little S. B., Jones R. A. MR urography in children: how we do it // Pediatr Radiol.- 2008.- Vol. 38 (Suppl 1).- Р S3 -17.

Vivier P. H., Dolores M., Taylor М. et al. MR urography in children. Part 1: how we do the F0 technique // Pediatr Radiol.- 2010.- Vol. 40 (5).- Р 732-738.

Vivier P. H., Dolores M., Taylor M., Dacher J. N. MR urography in children Part 2: how to use ImageJ MR urography processing software // Pediatr Radiol.- 2010.- Vol. 40(5).- Р 739-746.

Green D., Parker D. CTA and MRA: visualization without catheterization // Semin Ultrasound CT MR.- 2003.- Vol. 24(4).- Р 185-191.

ACR-NASCI-SPR practice guideline for the performance of body magnetic resonance angiography (MRA) American College of Radiology; [Accessed July 25, 2013]. http:// www.acr.org/~/media/D1BC4FB23D4B4005872FDDAE018E0CE7.pdf.

Hahn G., Sorge I., Gruhn B. et al. Pharmacokinetics and safety of gadobutrol-enhanced magnetic resonance imaging in pediatric patients // Invest Radiol.- 2009.- Vol. 44(12).- Р 776-783.

Bhargava R., Noga M. Safety and efficacy of gadobutrol-enhanced MRI in patients aged under 2 years - a single-center, observational study // Magnetic Resonance Insights.- 2013.- Vol. 6.- Р 1-12.

Frenzel T., Lengsfeld P., Schirmer H. et al. Stability of gadolinium-based magnetic resonance imaging contrast agents in human serum at 37 degrees C // Invest Radiol.- 2008.- Vol. 43(12).- Р 817-828.

Morcos S. K. Extracellular gadolinium contrast agents: differences in stability // Eur. J. Radiol. - 2008.- Vol. 66 (2).- Р 175-179.

Thomsen H. S., Morcos S. K., Almén T. Nephrogenic systemic fibrosis and gadolinium-based contrast media: updated ESUR Contrast Medium Safety Committee guidelines // Eur. Radiol.- 2013.- Vol. 23(2).- Р. 307-318.

Errante Y., Cirimele V., Mallio C. A. et al. Progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is associated with cumulative doses of intravenously administered gadodiamide in patients with normal renal function, suggesting dechelation // Invest Radiol. - 2014.- Vol. 49 (10).- Р. 685-690.

Kanda T., Osawa M., Oba H. et al. High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration // Radiology.- 2015.- Vol. 275(3).- Р. 803-809.

Foss C., Smith J. K. et al. Gadolinium-associated nephrogenic systemic fibrosis in a 9-year-old boy // Ortiz Pediatr Dermatol.- 2009.- Vol. 26 (5).- Р. 579-582.

Perez-Rodriguez J., Lai S., Ehst B. D. et al. Nephrogenic systemic fibrosis: incidence, associations, and effect of risk factor assessment - report of 33 cases // Radiology.- 2009.- Vol. 250 (2).- Р. 371-377.

Sato T., Ito К., Tamada Т. et al. Tissue gadolinium deposition in renally impaired rats exposed to different gadolinium-based MRI contrast agents: evaluation with inductively coupled plasma mass spectrometry (ICP-MS) // Magn Reson Imaging.- 2013.- Vol. 31 (8).- P. 1412-1417.

Tamrazi A., Vasanawala S. S. Functional hepatobiliary MR imaging in children // Pediatr Radiol.- 2011.- Vol. 41 (10).- Р. 1250-1258.

Yoon H. J., Jeon T. Y., Yoo S. Y. et al. Hepatic tumours in children with biliary atresia: single-centre experience in 13 cases and review of the literature // Clin. Radiol.- 2014.- Vol. 69 (3).- Р. e113-119

Voth M., Rosenberg M., Breuer J. Safety of gadobutrol, a new generation of contrast agents: experience from clinical trials and postmarketing surveillance // Invest Radiol.- 2011.- Vol. 46 (11).- Р. 663-671.

Dillman J. R., Ellis J. H., Cohan R. H. et al. Frequency and severity of acute allergic-like reactions to gadolinium-containing i.v. contrast media in children and adults // Am. J. Roentgenol.- 2007.- Vol. 189 (6).- Р. 1533-1538.

Hahn G. Open-label, Multicenter, Pharmacokinetic and Safety Study in Children Below 2 Years of Age Undergoing a Contrast-enhanced MRI with an Intravenous Injection of a Single Standard Dose of Gadobutrol // Abstract #SSM20-04. 2014 Radiological Society of North America (RNSA) Scientific Assembly and Annual Meeting, November 30 - December 5, 2014, Chicago, IL, USA, rsna2014.rsna.org/program/details/?emID = 14008140 (Accessed January 3, 2015)].

Brown J. J., Hynes M. R., Wible J. H. et al. Measurement of serum calcium concentration after administration of four gadolinium-based contrast agents to human volunteers // Am. J. Roentgenol.- 2007.- Vol. 189(6).- Р. 1539-1544.

Wible J. H., Tata P. N., Napoli A. M. et al. Pharmacokinetics of gadoversetamide injection, a gadolinium-based contrast agent, in pediatric patients // Magn Reson Imaging.- 2009.- Vol. 27 (4).- Р. 512-518.

Anzalone N., Scarabino Т., Venturi С. et al. Cerebral neoplastic enhancing lesions: multicenter, randomized, crossover intraindividual comparison between gadobutrol (1.0M) and gadoterate meglumine (0,5M) at 0.1 mmol Gd/kg body weight in a clinical setting // Eur. J. Radiol. - 2013.- Vol. 82(1).- Р. 139-145.

Hadizadeh D. R., Von Falkenhausen М., Kukuk G. M. et al. Contrast material for abdominal dynamic contrast-enhanced 3D MR angiography with parallel imaging: intraindividual equimolar comparison of a macrocyclic 1.0 M gadolinium chelate and a linear ionic 0,5 M gadolinium chelate // Am. J. Roentgenol.- 2010.- Vol. 194 (3).- Р. 821-829.

The authors declare that there are no conflicts of interest present.