References

ldt

Лучевая диагностика и терапия

Diagnostic radiology and radiotherapy

2079-5343

Baltic Medical Education Center

10.22328/2079-5343-2016-2-22-31

ldt-119

Research Article

ЛЕКЦИИ, ОБЗОРЫ

LECTURES AND REVIEWS

ЛУЧЕВАЯ ТЕРАПИЯ ОПУХОЛЕЙ ГОЛОВНОГО МОЗГА И ЭПИГЕНЕТИКА

LECTURES AND REVIEWS RADIATION THERAPY OF BRAIN TUMORS AND EPIGENETICS

Карташев

Артем Владимирович

Kartashev

A. F.

noemail@neicon.ru

Якубович

Елена Игоревна

Yakubovich

E. I.

noemail@neicon.ru

Российский научный центр радиологии и хирургических технологий; Северо-Западный государственный медицинский университет им. И. И. МечниковаРоссияRussian Research Centre for Radiology and Surgical Technologies; North-Western State Medical University named after I. I. MechnikovRussian Federation

Российский научный центр радиологии и хирургических технологийРоссияRussian Research Centre for Radiology and Surgical TechnologiesRussian Federation

2016

30062016

022231

2016

Карташев А.В., Якубович Е.И.

Kartashev A.F., Yakubovich E.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://radiag.bmoc-spb.ru/jour/article/view/119

Глиомы - самые распространенные первичные опухоли головного мозга, несмотря на внедрение инновационных технологий, у значительной доли пациентов наблюдается резистентность к проводимой радиотерапии и развиваются рецидивы. В ряде исследований было показано, что ключевую роль в канцерогенезе глиом играют эпигенетические изменения. Метилирование ДНК и модификация гистонов являются основными эпигенетическими механизмами регуляции экспрессии генов и, таким образом, модуляторами широкого спектра клеточных процессов, в том числе на чувствительность к облучению. Эпигенетические маркеры, ассоциированные с радиорезистентностью, перспективны в качестве предикторов ответа на лучевую терапию и прогноза. С другой стороны, имеющиеся данные позволяют предположить, что излучение, в свою очередь, индуцирует эпигенетическое перепрограммирование, что может повлиять на судьбу клеток или изменить клеточный ответ на последующее лучевое воздействие. Эпигенетические изменения потенциально могут быть медикаментозно скорректированы, поэтому они рассматриваются в качестве возможных мишеней для радиосенсибилизации опухолей. В данном обзоре представлено современное состояние проблемы взаимосвязи между эпигенетикой и ответом на лучевую терапию.

Gliomas are the most common primary intrinsic brain tumours and Ionizing radiation represents the most effective therapy for their treatment. However, despite successful adoption of innovative technologies, radiotherapy resistance and tumor recurrence still occur in a high proportion of patients. Thus there is great interest in understanding the underlying biology and developing new strategies to overcome radioresistance. The expanding investigation of glioma suggests that epigenetic changes play a critical roles in glioma genesis. DNA methylation and histone modification are key marks that regulate gene expression and thus modulate a wide range of cellular processes. The recent studies suggest that epigenetic state of tumor cell may affect сєіі sensitivity to radiation. Epigenetic markers associated with radioresistance hold promise as predictive biomarkers for therapy response and prognosis. On the other hand the obtained results suggest that radiation induces epigenetic reprogramming of cells which may influences the cell fate or alters the response to future exposure. As epigenetic alterations can potentially be reversed by drug treatment, they are interesting candidate targets for radiotherapy sensitizers. This review describes the current knowledge on epigenetics in radiotherapy.

глиомаэпигенетикалучевая терапияgliomaepigeneticradiotherapy

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The authors declare that there are no conflicts of interest present.