ldtЛучевая диагностика и терапияDiagnostic radiology and radiotherapy2079-5343Baltic Medical Education Center10.22328/2079-5343-2021-12-2-7-21ldt-617Research ArticleРЕДАКЦИОННАЯ СТАТЬЯEDITORIALНейрорадиологические и патоморфологические особенности опухолей, ассоциированных с  эпилепсиейNeuroradiological and pathomorphological features of epilepsy associated brain tumorsХалиловВ. С.KhalilovV. S.

Халилов Варис Садрутдинович  — кандидат медицинских наук, врач отделения магнитно-резонансной томографии; доцент кафедры неврологии, нейрохирургии и  медицинской генетики имени академика Л.О. Бадаляна педиатрического факультета

117198, Москва, ул. Москворечье, д. 20

117513, Москва, ул. Островитянова, д. 14

Varis S. Khalilov.

Moscow.

khalilov.mri@gmail.comХолинА. А.KholinA. A.

Холин Алексей Александрович  — доктор медицинских наук, профессор кафедры неврологии, нейрохирургии и медицинской генетики им. академика Л.О. Бадаляна педиатрического факультета

117513, Москва, ул. Островитянова, д. 14

 

Alexey A. Kholin.

Moscow.

DrKholin@mail.ruКисляковА. Н.KisyakovA. N.

Кисляков Алексей Николаевич — заведующий патологоанатомическим отделением

119049, Москва, 4-й Добрынинский пер., д. 1/9

Alexey N. Kisyakov.

Moscow.

alkislyakov@yandex.ruМедведеваН. А.MedvedevaN. A.

Медведева Наталья Александровна  — врач отделения магнитно-резонансной томографии

117198, Москва, ул. Москворечье, д. 20

Natalia A. Medvedeva.

Moscow.

niagara86@mail.ruБакаеваБ. Р.  BakaevaB. R.

Бакаева Бэла Руслановна — врач-рентгенолог, научный сотрудник

115551, Москва, Ореховый бульвар, д. 28

Bela R. Bakaeva.

Moscow.

belkis875@inbox.ruФедеральный научно-клинический центр детей и подростков; Российский национальный исследовательский медицинский университет имени Н. И. ПироговаРоссияFederal Research and Clinical Center for Children and Adolescents; Pirogov Russian National Research Medical UniversityRussian FederationРоссийский национальный исследовательский медицинский университет имени Н.И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian FederationМорозовская детская городская клиническая больницаРоссияMorozov Children Clinical HospitalRussian FederationФедеральный научно-клинический центр детей и подростковРоссияFederal Research and Clinical Center for Children and AdolescentsRussian FederationФедеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологийРоссияFederal Scientific and Clinical Center of Specialized Types of Medical Care and Medical TechnologiesRussian Federation202117102021122721Copyright © Халилов В.С., Холин А.А., Кисляков А.Н., Медведева Н.А., Бакаева Б.Р., 20212021Халилов В.С., Холин А.А., Кисляков А.Н., Медведева Н.А., Бакаева Б.Р.Khalilov V.S., Kholin A.A., Kisyakov A.N., Medvedeva N.A., Bakaeva B.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://radiag.bmoc-spb.ru/jour/article/view/617

Опухоли головного мозга представляют собой вторую по частоте этиологию у пациентов детского возраста с фокальными приступами, прошедших процедуру хирургического вмешательство по поводу фармакорезистентной эпилепсии. Эти новообразования имеют ряд отличительных особенностей от обнаруживаемых у взрослых пациентов, одной из которых является широкий полиморфизм структурной архитектоники при проведении нейрорадиологического обследования. Учитывая потрясающую биологическую стабильность этих опухолей, не во всех случаях проведения прехирургического обследования удается верифицировать наличие неопластического процесса в структуре эпилептогенного субстрата рутинными методами нейровизуализации. В некоторых сложных диагностических случаях требуется мультимодальный поход к визуализации и углубленное комплексное обследование для достоверной диагностики и успешности результатов эпилептической хирургии.

Brain tumors are the second most common etiology in pediatric patients with focal seizures undergoing surgery for drug-resistant epilepsy. These neoplasms have a number of distinctive features from those found in adult patients, one of which is a wide polymorphism of structural architectonics during neuroradiological examination. Given the tremendous biological stability of these tumors, not in all cases of pre-surgical examination it is possible to verify the presence of a neoplastic process in the structure of the epileptogenic substrate using routine neuroimaging methods. In some complex diagnostic cases, a multimodal imaging approach and in-depth complex examination are required for reliable diagnosis and success of the results of epileptic surgery.

нейронально-глиальные опухолиструктурная эпилепсиянейрорадиологияglio-neuronal tumorsstructural epilepsyneuroradiologyReferencesBlumcke I., Aronica E., Urbach H., Alexopoulos A., Gonzalez-Martinez J.A. A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors // Acta Neuropathol. 2014. Vol. 128. Р. 39–54. https://doi.org/10.1007/s00401-014-1288-9.Blumcke I., Aronica E., Urbach H., Alexopoulos A., Gonzalez-Martinez J.A. A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors // Acta Neuropathol. 2014. Vol. 128. Р. 39–54. https://doi.org/10.1007/s00401-014-1288-9.García-Fernández M., Fournier-Del Castillo C., Ugalde-Canitrot A. et al. Epilepsy surgery in children with developmental tumours // Seizure. 2011. Vol. 20, No. 8. Р. 616–627. https://doi.org/10.1016/j.seizure.2011.06.003.García-Fernández M., Fournier-Del Castillo C., Ugalde-Canitrot A. et al. Epilepsy surgery in children with developmental tumours // Seizure. 2011. Vol. 20, No. 8. Р. 616–627. https://doi.org/10.1016/j.seizure.2011.06.003.Luyken C., Blümcke I., Fimmers R. et al. The spectrum of long-term epilepsyassociated tumors: long term seizure and tumor outcome and neuro surgical aspects // Epilepsia. 2003. Vol. 44. Р. 822–830. doi: 10.1046/j.15281157.2003.56102.x.Luyken C., Blümcke I., Fimmers R. et al. The spectrum of long-term epilepsyassociated tumors: long term seizure and tumor outcome and neuro surgical aspects // Epilepsia. 2003. Vol. 44. Р. 822–830. doi: 10.1046/j.15281157.2003.56102.x.Slegers R.J., Blumcke I. Low-grade developmental and epilepsy associated brain tumors: a critical update 2020 // Acta Neuropathol. Commun. 2020. Vol. 8, No. 1. Р. 27. doi: 10.1186/s40478-020-00904-x. PMID: 32151273; PMCID: PMC7063704.Slegers R.J., Blumcke I. Low-grade developmental and epilepsy associated brain tumors: a critical update 2020 // Acta Neuropathol. Commun. 2020. Vol. 8, No. 1. Р. 27. doi: 10.1186/s40478-020-00904-x. PMID: 32151273; PMCID: PMC7063704.Blümcke I., Aronica E., Becker A. et al. Low-grade epilepsy-associated neuroepithelial tumours — the 2016 WHO classification // Nature Reviews Neurology. 2016. Vol. 12, No. 12. Р. 732–740. doi: 10.1038/nrneurol.2016.173scihub.se/10.1038/nrneurol.2016.173.Blümcke I., Aronica E., Becker A. et al. Low-grade epilepsy-associated neuroepithelial tumours — the 2016 WHO classification // Nature Reviews Neurology. 2016. Vol. 12, No. 12. Р. 732–740. doi: 10.1038/nrneurol.2016.173scihub.se/10.1038/nrneurol.2016.173.Khalilov V., Kholin A., Gazdieva Kh., Kostylev F. Neoplastic Process Verification of Unclear Cortical Substrates in Children with Epilepsy // J. Epilepsia. 2018. Vol. 59, No. 11, issue 3. Р. 120–121. doi: 10.1111/epi.14612.Khalilov V., Kholin A., Gazdieva Kh., Kostylev F. Neoplastic Process Verification of Unclear Cortical Substrates in Children with Epilepsy // J. Epilepsia. 2018. Vol. 59, No. 11, issue 3. Р. 120–121. doi: 10.1111/epi.14612.Paudel K., Borofsky S., Jones R.V., Levy L.M. Dysembryoplastic neuroepithelial tumor with atypical presentation: MRI and diffusion tensor characteristics // J. Radiol. Case Reports. 2013. Vol. 7, No. 11. Р. 7–14. doi: 10.3941/jrcr.v7i11.1559.Paudel K., Borofsky S., Jones R.V., Levy L.M. Dysembryoplastic neuroepithelial tumor with atypical presentation: MRI and diffusion tensor characteristics // J. Radiol. Case Reports. 2013. Vol. 7, No. 11. Р. 7–14. doi: 10.3941/jrcr.v7i11.1559.Zanello M., Pages M., Tauziede-Espariat A. et al. Clinical, imaging, Histopathological and molecular characterization of anaplastic Ganglioglioma // J. Neuropathol. Exp. Neurol. 2016. Vol. 75. Р. 971–980. https://doi.org/10.1093/jnen/nlw0741.Zanello M., Pages M., Tauziede-Espariat A. et al. Clinical, imaging, Histopathological and molecular characterization of anaplastic Ganglioglioma // J. Neuropathol. Exp. Neurol. 2016. Vol. 75. Р. 971–980. https://doi.org/10.1093/jnen/nlw0741.Yeon-Lim Suh. Dysembryoplastic Neuroepithelial Tumor // J. Pathol. Transl. Med. 2015. Vol. 49, No. 6. Р. 438–449. doi: 10.4132/jptm.2015.10.05.Yeon-Lim Suh. Dysembryoplastic Neuroepithelial Tumor // J. Pathol. Transl. Med. 2015. Vol. 49, No. 6. Р. 438–449. doi: 10.4132/jptm.2015.10.05.Chassoux F., Daumas‐Duport C. Dysembryoplastic neuroepithelial tumors: Where are we now? // Epilepsia. 2013. Vol. 54. Р. 129–134. https://doi.org/10.1111/epi.12457.Chassoux F., Daumas‐Duport C. Dysembryoplastic neuroepithelial tumors: Where are we now? // Epilepsia. 2013. Vol. 54. Р. 129–134. https://doi.org/10.1111/epi.12457.Халилов В.С., Холин А.А., Газдиева Х.Ш., Кисляков А.Н., Заваденко Н.Н. Особенности нейрорадиологической картины ганглиоглиомы на примере 20 клинических случаев // Журнал неврологии и психиатрии им. С.С.Корсакова. 2020. Т. 120, № 11. С. 90–98. https://doi.org/10.17116/jnevro202012011190Khalilov V.S., Kholin A.A., Gazdieva Kh.Sh., Kislyakov A.N., Zavadenko N.N. Features of the neuroradiological picture of ganglioglioma on the example of 20 clinical cases. Journal of Neurology and Psychiatry name after S.S.Korsakov, 2020, Vol. 120, No. 11, рр. 90–98. https://doi.org/10.17116/jnevro202012011190 (In Russ).Chassoux F., Rodrigo S., Mellerio C. et al. Dysembryoplastic neuroepithelial tumors: an MRI-based scheme for epilepsy surgery // Neurology. 2012. Vol. 79. Р. 1699–1707. doi: https://doi.org/10.1212/WNL.0b013e31826e9aa9.Chassoux F., Rodrigo S., Mellerio C. et al. Dysembryoplastic neuroepithelial tumors: an MRI-based scheme for epilepsy surgery // Neurology. 2012. Vol. 79. Р. 1699–1707. doi: https://doi.org/10.1212/WNL.0b013e31826e9aa9.Fernandez C., Girard N., Paz Paredes F. et al. The usefulness of MRI in the diagnosis of disembryoplastic neuroepithelial tumor in children: a study of 14 cases // American Journal of Neuroradiology. 2003. Vol. 24, No. 5. Р. 829–834.Fernandez C., Girard N., Paz Paredes F. et al. The usefulness of MRI in the diagnosis of disembryoplastic neuroepithelial tumor in children: a study of 14 cases // American Journal of Neuroradiology. 2003. Vol. 24, No. 5. Р. 829–834.Алиханов А.А., Генералов В.О., Демушкина А.А., Перепелова Е.М., Шимановский Н.Л., Чадаев В.А. Визуализация эпилептогенных поражений головного мозга у детей. М.: Издательский дом Видар, 2009. Глава 5. С. 199–212.Alikhanov A.A., Generalov V.O., Demushkina А.А. et al. The visualization of epileptogenic brain damages in children. Moscow: Izdatelskiy dom Vidar; 2009. Chapter 5. Р. 199–212 (In Russ.)Ostertun B., Wolf H.K., Campos M.G. et al. Dysembryoplastic neuroepithelial tumors: MR and CT evaluation // Am. J. Neuroradiol. 1996. Vol. 17, No. 3. Р. 419–430. PMID: 8881234 (428).Ostertun B., Wolf H.K., Campos M.G. et al. Dysembryoplastic neuroepithelial tumors: MR and CT evaluation // Am. J. Neuroradiol. 1996. Vol. 17, No. 3. Р. 419–430. PMID: 8881234 (428).Blumcke I., Thom M., Aronica E. et al. The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE. Diagnostic Metods Commission // Epilepsia. 2011. Vol. 52, No. 1, рр. 158–174. https://doi.org/10.1111/j.1528-1167.2010.02777.x.Blumcke I., Thom M., Aronica E. et al. The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE. Diagnostic Metods Commission // Epilepsia. 2011. Vol. 52, No. 1, рр. 158–174. https://doi.org/10.1111/j.1528-1167.2010.02777.x.Cossu M., Fuschillo D., Bramerio M. et al. Epilepsy surgery of focal cortical dysplasia-associated tumors // Epilepsia. 2013. Vol. 54, No. 9. Р. 115–122. https://doi.org/10.1111/epi.12455.Cossu M., Fuschillo D., Bramerio M. et al. Epilepsy surgery of focal cortical dysplasia-associated tumors // Epilepsia. 2013. Vol. 54, No. 9. Р. 115–122. https://doi.org/10.1111/epi.12455.Al-Hajri A., Al-Mughairi S., Somani A. et al. Pathology–MRI Correlations in Diffuse Low-Grade Epilepsy Associated Tumors // Journal of Neuropathology and Experimental Neurology. 2017. Vol. 76. Р. 1023–1033. doi: 10.1093/jnen/nlx090.Al-Hajri A., Al-Mughairi S., Somani A. et al. Pathology–MRI Correlations in Diffuse Low-Grade Epilepsy Associated Tumors // Journal of Neuropathology and Experimental Neurology. 2017. Vol. 76. Р. 1023–1033. doi: 10.1093/jnen/nlx090.Bodi I., Selway R., Bannister P. et al. Diffuse form of dysembryoplastic neuroepithelial tumour: the histological and immunohistochemical features of a distinct entity showing transition to dysembryoplastic neuroepithelial tumour and ganglioglioma // Neuropathol. Appl. Neurobiol. 2012. Vol. 38, No. 5. Р. 411–425. https://doi.org/10.1111/j.1365-2990.2011.01225.x.Bodi I., Selway R., Bannister P. et al. Diffuse form of dysembryoplastic neuroepithelial tumour: the histological and immunohistochemical features of a distinct entity showing transition to dysembryoplastic neuroepithelial tumour and ganglioglioma // Neuropathol. Appl. Neurobiol. 2012. Vol. 38, No. 5. Р. 411–425. https://doi.org/10.1111/j.1365-2990.2011.01225.x.Pekmezci M., Villanueva-Meyer J.E., Goode B. et al. The genetic landscape of ganglioglioma // Acta Neuropathol. Commun. 2018. Vol. 6, No. 1. Р. 47. doi: 10.1186/s40478–018–0551-z. PMID 29880043.Pekmezci M., Villanueva-Meyer J.E., Goode B. et al. The genetic landscape of ganglioglioma // Acta Neuropathol. Commun. 2018. Vol. 6, No. 1. Р. 47. doi: 10.1186/s40478–018–0551-z. PMID 29880043.Terrier LM., Bauchet L., Rigau V. et al. Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database // NeuroOncol. 2017. Vol. 19, No. 5. Р. 678–688. doi: 10.1093/neuonc/now186. PMID 28453747.Terrier LM., Bauchet L., Rigau V. et al. Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database // NeuroOncol. 2017. Vol. 19, No. 5. Р. 678–688. doi: 10.1093/neuonc/now186. PMID 28453747.Prayson R.A., Napekoski K.M. Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases // Hum. Pathol. 2012. Vol. 43, No. 7. Р. 1113–1118. https://doi.org/10.1016/j.humpath.2011.08.023.Prayson R.A., Napekoski K.M. Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases // Hum. Pathol. 2012. Vol. 43, No. 7. Р. 1113–1118. https://doi.org/10.1016/j.humpath.2011.08.023.Holthausen H., Winkler P., Pieper T. et al. Ganglioglioma mimicking transmantle focal cortical dysplasia in a two-year old child with intractable epilepsy // Aktuelle Neurologie. 2006. Vol. 33. P. 1446. https://doi.org/10.1055/s-2006-953490.Holthausen H., Winkler P., Pieper T. et al. Ganglioglioma mimicking transmantle focal cortical dysplasia in a two-year old child with intractable epilepsy // Aktuelle Neurologie. 2006. Vol. 33. P. 1446. https://doi.org/10.1055/s-2006-953490.Ratilal B., McEvoy A., Sisodya S., Thom M., Toma A. Diffuse cerebral gangliocytoma in an adult with late-onset refractory epilepsy // Neuropathology and Applied Neurobiology. 2007. Vol. 33, No. 6. Р. 706–709. https://doi.org/10.1111/j.1365-2990.2007.00861.x.Ratilal B., McEvoy A., Sisodya S., Thom M., Toma A. Diffuse cerebral gangliocytoma in an adult with late-onset refractory epilepsy // Neuropathology and Applied Neurobiology. 2007. Vol. 33, No. 6. Р. 706–709. https://doi.org/10.1111/j.1365-2990.2007.00861.x.Kabat J., Król P. Focal cortical dysplasia — review // Polish journal of radiology. 2012. Vol. 77, No. 2. Р. 35–43. https://doi.org/10.12659/pjr.882968.Kabat J., Król P. Focal cortical dysplasia — review // Polish journal of radiology. 2012. Vol. 77, No. 2. Р. 35–43. https://doi.org/10.12659/pjr.882968.Мухин К.Ю. Фокальные кортикальные дисплазии: клинико-электро-нейровизуализационные характеристики // Русский журнал детской неврологии. 2016. № 11. С. 8–24. doi: 10.17650/2073-8803-2016-11-2-8-24Mukhin K.Y. Focal Cortical Dysplasias: Clinical and Electro-Neuroimaging Characteristics. Russian Journal of Child Neurology, 2016, Vol. 11, No. 2, рр. 8–24 (In Russ.) doi: 10.17650/2073-8803-2016-11-2-8-24.Wei C., Guo G., Mikulis D. Tumor Effects on Cerebral White Matter as Characterized by Diffusion Tensor Tractography. Canadian Journal of Neurological Sciences // Journal Canadien Des Sciences Neurologiques. 2007. Vol. 34, No. 1. Р. 62–68. doi: 10.1017/S0317167100005801.Wei C., Guo G., Mikulis D. Tumor Effects on Cerebral White Matter as Characterized by Diffusion Tensor Tractography. Canadian Journal of Neurological Sciences // Journal Canadien Des Sciences Neurologiques. 2007. Vol. 34, No. 1. Р. 62–68. doi: 10.1017/S0317167100005801.Wolf R.L., Wang J., Wang P.S. et al. Grading of CNS Neoplasms Using Continuous Arterial Spin Labeled Perfusion MR Imaging at 3 Tesla // J. Magn. Reson. Imaging. 2005. Vol. 22. Р. 475–482. doi: 10.1002/jmri.20415 Published online 13 September 2005 in Wiley Inter Science (www.interscience.wiley.com).Wolf R.L., Wang J., Wang P.S. et al. Grading of CNS Neoplasms Using Continuous Arterial Spin Labeled Perfusion MR Imaging at 3 Tesla // J. Magn. Reson. Imaging. 2005. Vol. 22. Р. 475–482. doi: 10.1002/jmri.20415 Published online 13 September 2005 in Wiley Inter Science (www.interscience.wiley.com).Blauwblomme T., Boddaert N., Chemaly N. et al. Arterial spin labeling MRI: a step forward in noninvasive delineation of focal cortical dysplasia in children // Epilepsy Res. 2014. Vol. 108. Р. 1932–1939. doi: https://doi.org/10.1016/j.eplepsyres.2014.09.029.Blauwblomme T., Boddaert N., Chemaly N. et al. Arterial spin labeling MRI: a step forward in noninvasive delineation of focal cortical dysplasia in children // Epilepsy Res. 2014. Vol. 108. Р. 1932–1939. doi: https://doi.org/10.1016/j.eplepsyres.2014.09.029.Yeom K.W., Mitchell L.A., Lober R.M. et al. Arterial Spin-Labeled Perfusion of Pediatric Brain Tumors // American Journal of Neuroradiology February. 2014. Vol. 35, No. 2. Р. 395–401. doi: https://doi.org/10.3174/ajnr.A3670.Yeom K.W., Mitchell L.A., Lober R.M. et al. Arterial Spin-Labeled Perfusion of Pediatric Brain Tumors // American Journal of Neuroradiology February. 2014. Vol. 35, No. 2. Р. 395–401. doi: https://doi.org/10.3174/ajnr.A3670.Koeller K.K., Henry J.M. Superficial Gliomas: Radiologic-Pathologic Correlation // RadioGraphics. 2001. Nov-Dec. Vol. 21, No. 6. Р. 1533–1556. PMID: 11706224. doi: 10.1148/радиография.21.6.g01nv051533.Koeller K.K., Henry J.M. Superficial Gliomas: Radiologic-Pathologic Correlation // RadioGraphics. 2001. Nov-Dec. Vol. 21, No. 6. Р. 1533–1556. PMID: 11706224. doi: 10.1148/радиография.21.6.g01nv051533.Bodi I., Curran O., Selway R. et al. Two cases of multinodular and vacuolating neuronal tumour // Acta neuropathologica communications. Vol. 2, No. 7. 1–10. doi: 10.1186/2051-5960-2-7 —Pubmed.Bodi I., Curran O., Selway R. et al. Two cases of multinodular and vacuolating neuronal tumour // Acta neuropathologica communications. Vol. 2, No. 7. 1–10. doi: 10.1186/2051-5960-2-7 —Pubmed.Prayson R.A. Angiocentric Glioma: A Review of Clinicopathologic Features // OBM Neurobiology. 2018. Vol. 2, No. 4. Р. 1–10. doi: 10.21926/obm.neurobiol.1804015.Prayson R.A. Angiocentric Glioma: A Review of Clinicopathologic Features // OBM Neurobiology. 2018. Vol. 2, No. 4. Р. 1–10. doi: 10.21926/obm.neurobiol.1804015.Chaudhari J.P., Kothari K.S., Pandya T.P., Goel N.A. Angiocentric glioma: Report of a rare case presenting with psychosis // Asian J. Neurosurg. 2018. Vol. 13. Р. 1186–1192. doi: 10.4103/ajns.AJNS_371_16.Chaudhari J.P., Kothari K.S., Pandya T.P., Goel N.A. Angiocentric glioma: Report of a rare case presenting with psychosis // Asian J. Neurosurg. 2018. Vol. 13. Р. 1186–1192. doi: 10.4103/ajns.AJNS_371_16.Kodama S., Shirota Y., Hagiwara A. et al. Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient // Clinical Neurophysiology Practice. 2019. Vol. 4. Р. 164–167. doi: 10.1007/s00381-019-04496-3.Kodama S., Shirota Y., Hagiwara A. et al. Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient // Clinical Neurophysiology Practice. 2019. Vol. 4. Р. 164–167. doi: 10.1007/s00381-019-04496-3.Dias L., Candela-Cantó S., Jou C. et al. Multinodular and vacuolating neuronal tumor associated with focal cortical dysplasia in a child with refractory epilepsy: a case report and brief review of literature // Child’s Nervous System. 2020. Vol. 36. Р. 1557–1561. doi: 10.1007/s00381-019-04496-3.Dias L., Candela-Cantó S., Jou C. et al. Multinodular and vacuolating neuronal tumor associated with focal cortical dysplasia in a child with refractory epilepsy: a case report and brief review of literature // Child’s Nervous System. 2020. Vol. 36. Р. 1557–1561. doi: 10.1007/s00381-019-04496-3.Nunes R.H, Hsu C.C., da Rocha A.J. do et al. Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: A New «Leave Me Alone» Lesion with a Characteristic Imaging Pattern // American Journal of Neuroradiology. 2017. Vol. 38, No. 10. Р. 1–6. doi: 10.3174/ajnr.A5281.Nunes R.H, Hsu C.C., da Rocha A.J. do et al. Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: A New «Leave Me Alone» Lesion with a Characteristic Imaging Pattern // American Journal of Neuroradiology. 2017. Vol. 38, No. 10. Р. 1–6. doi: 10.3174/ajnr.A5281.Babini М., Giulioni M., Galassi E. et al. Seizure outcome of surgical treatment of focal epilepsy associated with low-grade tumors in children: Clinical article // J. Neurosurg. Pediatrics. 2013. Vol. 11. Р. 214–223. doi: 10.3171/2012.11.PEDS12137.Babini М., Giulioni M., Galassi E. et al. Seizure outcome of surgical treatment of focal epilepsy associated with low-grade tumors in children: Clinical article // J. Neurosurg. Pediatrics. 2013. Vol. 11. Р. 214–223. doi: 10.3171/2012.11.PEDS12137.Selvanathan S.K., Hammouche S., Salminen H.J., Jenkinson M.D. Outcome and prognostic features in anaplastic ganglioglioma: Analysis of cases from the SEER database // Journal of Neuro-Oncology. 2011. Vol. 105, No. 3. Р. 539–545. doi: 10.1007/s11060-011-0615-4.Selvanathan S.K., Hammouche S., Salminen H.J., Jenkinson M.D. Outcome and prognostic features in anaplastic ganglioglioma: Analysis of cases from the SEER database // Journal of Neuro-Oncology. 2011. Vol. 105, No. 3. Р. 539–545. doi: 10.1007/s11060-011-0615-4.Im S.H., Chung C.K., Cho B.K. et al. Intracranial ganglioglioma: preoperative characteristics and oncologic outcome after surgery // J. Neurooncol. 2002. Vol. 59, No. 2. Р. 173–183. doi: 10.1023/a:1019661528350. PMID: 12241112.Im S.H., Chung C.K., Cho B.K. et al. Intracranial ganglioglioma: preoperative characteristics and oncologic outcome after surgery // J. Neurooncol. 2002. Vol. 59, No. 2. Р. 173–183. doi: 10.1023/a:1019661528350. PMID: 12241112.Chao L.V., Tao X.B., Yang K.J. et al. Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature // Oncol Lett. 2013. Vol. 6, No. 4. Р. 907–914. Published online 2013 Jul 22. doi: 10.3892/ol.2013.1480.Chao L.V., Tao X.B., Yang K.J. et al. Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature // Oncol Lett. 2013. Vol. 6, No. 4. Р. 907–914. Published online 2013 Jul 22. doi: 10.3892/ol.2013.1480.

The authors declare that there are no conflicts of interest present.