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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ldt</journal-id><journal-title-group><journal-title xml:lang="ru">Лучевая диагностика и терапия</journal-title><trans-title-group xml:lang="en"><trans-title>Diagnostic radiology and radiotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-5343</issn><publisher><publisher-name>Baltic Medical Education Center</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22328/2079-5343-2021-12-2-59-69</article-id><article-id custom-type="elpub" pub-id-type="custom">ldt-623</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Рентгенологическая картина респираторного дистресс-синдрома у новорожденных с низкой и экстремально низкой массой тела</article-title><trans-title-group xml:lang="en"><trans-title>X-ray image of respiratory distress syndrome in newborns with low and extremely low birth weight</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2072-1692</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Красильникова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasilnikova</surname><given-names>Е. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Красильникова Елена Александровна — врач-рентгенолог</p><p>634063, Томск, ул. Мичурина, д. 105</p><p>SPIN-код 1245–3402</p></bio><bio xml:lang="en"><p>Elena A. Krasilnikova</p><p>Tomsk</p></bio><email xlink:type="simple">krasatr85@sibmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0025-2147</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Завадовская</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Zavadovskaya</surname><given-names>V. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Завадовская Вера Дмитриевна — доктор медицинских наук, профессор, и.о. заведующий кафедрой лучевой диагностики и лучевой терапии</p><p>634050, г. Томск, Московский тр., д. 2</p><p>SPIN-код 7905–8363</p></bio><bio xml:lang="en"><p> </p><p>Tomsk</p></bio><email xlink:type="simple">wdzav@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2133-665X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Желев</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhelev</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Желев Виктор Александрович — доктор медицинских наук, профессор, заведующий кафедрой госпитальной терапии</p><p>634050, г. Томск, Московский тр., д. 2</p><p>SPIN-код 2088–2865</p></bio><bio xml:lang="en"><p>Victor A. Zhelev</p><p>Tomsk</p></bio><email xlink:type="simple">dozd5@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0453-0431</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Люлько</surname><given-names>Ю. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyulko</surname><given-names>J. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Люлько Юлия Олеговна — ординатор кафедры лучевой диагностики и лучевой терапии</p><p>634050, г. Томск, Московский тр., д. 2</p><p>SPIN-код 2335–2845;</p></bio><bio xml:lang="en"><p>Julia O. Lyulko</p><p>Tomsk</p></bio><email xlink:type="simple">jylialyilia@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3903-2934</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ермоленко</surname><given-names>С. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ermolenko</surname><given-names>S. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ермоленко Сергей Прокопьевич — кандидат медицинских наук, ассистент кафедры госпитальной педиатрии</p><p>634050, г. Томск, Московский тр., д. 2</p><p>SPIN-код 9195–4393</p></bio><bio xml:lang="en"><p>Sergey P. Ermolenko</p><p>Tomsk</p></bio><email xlink:type="simple">erserpro@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0025-2147</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зоркальцев</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zorkaltsev</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зоркальцев Максим Александрович — доктор медицинских наук, доцент, доцент кафедры лучевой диагностики и лучевой терапии</p><p>634050, г. Томск, Московский тр., д. 2</p><p>SPIN-код 3769–8560</p></bio><bio xml:lang="en"><p>Maksim A. Zorkaltsev</p><p>Tomsk</p></bio><email xlink:type="simple">zorkaltsev@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Международный институт биологических систем имени Сергея Березина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>International Institute of Biological Systems named after Sergei Berezin</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>18</day><month>10</month><year>2021</year></pub-date><volume>12</volume><issue>2</issue><fpage>59</fpage><lpage>69</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Красильникова Е.А., Завадовская В.Д., Желев В.А., Люлько Ю.О., Ермоленко С.П., Зоркальцев М.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Красильникова Е.А., Завадовская В.Д., Желев В.А., Люлько Ю.О., Ермоленко С.П., Зоркальцев М.А.</copyright-holder><copyright-holder xml:lang="en">Krasilnikova Е.А., Zavadovskaya V.D., Zhelev V.A., Lyulko J.O., Ermolenko S.P., Zorkaltsev M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://radiag.bmoc-spb.ru/jour/article/view/623">https://radiag.bmoc-spb.ru/jour/article/view/623</self-uri><abstract><sec><title>Введение</title><p>Введение. Респираторный дистресс-синдром (РДС) характеризуется незрелостью легочной ткани, недостаточностью сурфактанта и является частой причиной смерти у недоношенных новорожденных. Рентгенография является основным методом для определения причин и степени выраженности респираторной недостаточности у новорожденных.</p></sec><sec><title>Цель</title><p>Цель. Систематизация результатов рентгенологического исследования легких новорожденных с различной степенью недоношенности, сопоставленных с аутопсийными данными.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Выполнен анализ рентгенологических данных и секционного материала 32 недоношенных новорожденных с низкой и экстремально низкой массой тела, умерших с клиническими проявлениями РДС.</p></sec><sec><title>Результаты исследования</title><p>Результаты исследования. В статье приведен сравнительный анализ различных типов рентгенологических изменений легких (ретикуло-нодулярный легочный рисунок (n=10), ячеистая деформация легочного рисунка (n=5), «воздушная бронхограмма» (n=20), синдром «утечки воздуха» (n=6), очагово-сливные тени/инфильтративно-подобные фокусы затемнения (n=9)) и результатов аутопсий недоношенных новорожденных.</p></sec><sec><title>Заключение</title><p>Заключение. Наибольшее количество совпадений рентгенологических и гистологических данных имело место при БЛД (80%), наименьшее — при легочных геморрагиях (20%). Совпадение заключений при пневмонии и болезни ГМ — в 58–56% соответственно. Сложность дифференциальной диагностики рентгенологической картины легких у маловесных новорожденных заключается в частом сочетании патологических состояний. У 15 (53,6%) новорожденных при отсутствии критериев сурфактантной недостаточности на фоне респираторной поддержки развивалась дыхательная недостаточность с широким спектром патологических изменений в легких.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Respiratory distress syndrome (RDS) is characterized by immaturity of lung tissue, surfactant deficiency and is a common cause of mortality in premature infants. X-ray is the main method for determining the causes and severity of respiratory failure in newborns.</p></sec><sec><title>Purpose</title><p>Purpose. Systematization of the results of X-ray examination of the lungs of newborns with varying degrees of prematurity, compared with autopsy data.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The analysis of X-ray data and sectional material of 32 premature infants with low and extremely low body weight who died with clinical manifestations of RDS was performed.</p></sec><sec><title>Research results</title><p>Research results. The article provides a comparative analysis of various types of radiological changes in the lungs (reticulo-nodular pulmonary pattern (n=10), cellular deformity of the pulmonary pattern (n=5), «air bronchogram» (n=20), «air leakage» syndrome (n=6), focal-confluent shadows/infiltrative-like foci of darkening (n=9)) and autopsy results of premature newborns.</p></sec><sec><title>Conclusion</title><p>Conclusion. The greatest number of coincidences of radiological and histological data took place in BPD (80%), the smallest — in pulmonary hemorrhages (20%). The coincidence of conclusions for pneumonia and GM disease is 58–56%, respectively. Difficulty in the differential diagnosis of the X-ray picture of the lungs in low birth-weight infants lies in the frequent combination of pathological conditions. Respiratory failure with a wide range of pathological changes in the lungs developed in 15 (53,6%) newborns in the absence of criteria for surfactant insufficiency against the background of respiratory support.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>респираторный дистресс-синдром</kwd><kwd>недоношенные новорожденные</kwd><kwd>рентгенологические изменения легких</kwd><kwd>гиалиновые мембраны</kwd><kwd>легочные геморрагии</kwd><kwd>бронхолегочная дисплазия</kwd><kwd>пневмония</kwd></kwd-group><kwd-group xml:lang="en"><kwd>respiratory distress syndrome</kwd><kwd>premature infants</kwd><kwd>X-ray changes in the lungs</kwd><kwd>hyaline membranes</kwd><kwd>pulmonary hemorrhages</kwd><kwd>bronchopulmonary dysplasia</kwd><kwd>pneumonia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma D., Padmavathi I.V., Tabatabaii S.A., Farahbakhsh N. Late preterm: a new high risk group in neonatology // J. Matern. Fetal Neonatal Med. 2019. Oct. 1. Р. 1–14, doi: 10.1080/14767058.2019.1670796.</mixed-citation><mixed-citation xml:lang="en">Sharma D., Padmavathi I.V., Tabatabaii S.A., Farahbakhsh N. Late preterm: a new high risk group in neonatology // J. Matern. Fetal Neonatal Med. 2019. Oct. 1. Р. 1–14, doi: 10.1080/14767058.2019.1670796.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Байбарина Е.Н., Антонов А.Г., Ленюшкина А.А. Клинические рекомендации по уходу за новорожденными с экстремально низкой массой тела при рождении // Вопросы практической педиатрии. 2006. Т. 4, № 1. С. 96–97.</mixed-citation><mixed-citation xml:lang="en">Baybarina E.N., Antonov A.G., Lenyushkina A.A. Clinical rivers care recommendations for newborns with extremely low birth weight. Practical questions pediatrics, 2006, Vol. 4, No. 1. Р. 96–97 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Овсянников Д.Ю., Кузьменко Л.Г., Дегтярева Е.А., Кустова О.В., Болибок А.М., Маркарян О.В., Пагадаева Н.П., Полянин Д.В. Возможности высокоразрешающей компьютерной томографии в диагностике бронхолегочной дисплазии у детей первых двух лет жизни // Педиатрия. Журнал им. Г.Н.Сперанского. 2010. № 1.</mixed-citation><mixed-citation xml:lang="en">Ovsyannikov D.Yu., Kuzmenko L.G., Degtyareva E.A., Kustova O.V., Bolibok A.M., Markaryan O.V., Pagadaeva  N.P., Polyanin D.V. Possibilities of high-resolution computed tomography in the diagnosis of bronchopulmonary dysplasia in children during the first two years of life. Pediatrics. Journal them. G.N.Speransky, 2010, No. 1. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Thébaud В., Goss K.N., Laughon M. et al. Bronchopulmonary dysplasia: Author manuscript // Nat. Rev. Dis Primers. 2019. Nov. 14, Vol. 5, No. 1. Р. 78. doi: 10.1038/s41572–019–0127–7.</mixed-citation><mixed-citation xml:lang="en">Thébaud В., Goss K.N., Laughon M. et al. Bronchopulmonary dysplasia: Author manuscript // Nat. Rev. Dis Primers. 2019. Nov. 14, Vol. 5, No. 1. Р. 78. doi: 10.1038/s41572–019–0127–7.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Dominguez MC, Alvares BR. Pulmonary atelectasis in newborns with clinically treatable diseases who are on mechanical ventilation: clinical and radiological aspects // Radiol. Bras. 2018. Vol. 51, No. 1. Р. 20–25. doi: 10.1590/0100-3984.2016.0157.</mixed-citation><mixed-citation xml:lang="en">Dominguez MC, Alvares BR. Pulmonary atelectasis in newborns with clinically treatable diseases who are on mechanical ventilation: clinical and radiological aspects // Radiol. Bras. 2018. Vol. 51, No. 1. Р. 20–25. doi: 10.1590/0100-3984.2016.0157.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Reuter S., Moser C., Baack M. // Pediatr Rev. 2014. Oct; Vol. 35, No. 10. Р. 417–428; quiz 429. doi: 10.1542/pir.35-10-417.</mixed-citation><mixed-citation xml:lang="en">Reuter S., Moser C., Baack M. // Pediatr Rev. 2014. Oct; Vol. 35, No. 10. Р. 417–428; quiz 429. doi: 10.1542/pir.35-10-417.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Agrons G.A., Courtney S.E., Stocker J.Th., Markowitz R.I. Lung Disease in Premature Neonates: Radiologic-Pathologic Correlation // Anales de Radiología México. 2005. Vol. 4, No. 3. Р. 1047–1073. doi: 10.1148/rg.254055019.</mixed-citation><mixed-citation xml:lang="en">Agrons G.A., Courtney S.E., Stocker J.Th., Markowitz R.I. Lung Disease in Premature Neonates: Radiologic-Pathologic Correlation // Anales de Radiología México. 2005. Vol. 4, No. 3. Р. 1047–1073. doi: 10.1148/rg.254055019.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lovrensky J. Lung ultrasonography of pulmonary complications in preterm infants with respiratory distress syndrome // Upsala Journal of Medical Sciences. 2012. Vol. 117. Р. 10–17. doi: 10.3109/03009734.2011.643510.</mixed-citation><mixed-citation xml:lang="en">Lovrensky J. Lung ultrasonography of pulmonary complications in preterm infants with respiratory distress syndrome // Upsala Journal of Medical Sciences. 2012. Vol. 117. Р. 10–17. doi: 10.3109/03009734.2011.643510.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lee M., Wu К., Yu A., Roumiantsev S., Shailam R., Nimkin K., Sagar P. Pulmonary hemorrhage in neonatal respiratory distress syndrome: Radiographic evolution, course, complications and long-term clinical outcomes // J. Neonatal. Perinatal. Med. 2019. Vol. 12, No. 2. Р. 161–171. doi: 10.3233/NPM-1867.</mixed-citation><mixed-citation xml:lang="en">Lee M., Wu К., Yu A., Roumiantsev S., Shailam R., Nimkin K., Sagar P. Pulmonary hemorrhage in neonatal respiratory distress syndrome: Radiographic evolution, course, complications and long-term clinical outcomes // J. Neonatal. Perinatal. Med. 2019. Vol. 12, No. 2. Р. 161–171. doi: 10.3233/NPM-1867.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hiles М., Culpan A.-M., Watts С., Munyombwe Т., Wolstenhulme S. Neonatal respiratory distress syndrome: Chest X-ray or lung ultrasound. A systematic review // Ultrasound. 2017. Vol. 25, No. 2. Р. 80–91, doi: 10.1177/1742271X16689374.</mixed-citation><mixed-citation xml:lang="en">Hiles М., Culpan A.-M., Watts С., Munyombwe Т., Wolstenhulme S. Neonatal respiratory distress syndrome: Chest X-ray or lung ultrasound. A systematic review // Ultrasound. 2017. Vol. 25, No. 2. Р. 80–91, doi: 10.1177/1742271X16689374.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Shui-Wen Chen 1, Wei Fu, Jing Liu, Yan Wang. Routine application of lung ultrasonography in the neonatal intensive care unit // Observational Study Medicine (Baltimore). 2017. Vol. 96, No. 2. Р. e5826, doi: 10.1097/MD.0000000000005826.</mixed-citation><mixed-citation xml:lang="en">Shui-Wen Chen 1, Wei Fu, Jing Liu, Yan Wang. Routine application of lung ultrasonography in the neonatal intensive care unit // Observational Study Medicine (Baltimore). 2017. Vol. 96, No. 2. Р. e5826, doi: 10.1097/MD.0000000000005826.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Park Ji Soo, Choi Yun Jung, Kim Young Tae et al. Pediatric Case Report on an Interstitial Lung Disease with a Novel Mutation of SFTPC Successfully Treated with Lung Transplantation // J. Korean. Med. Sci. 2018. May 28; Vol. 33, No. 22. e159. doi: 10.3346/jkms.2018.33.e159.</mixed-citation><mixed-citation xml:lang="en">Park Ji Soo, Choi Yun Jung, Kim Young Tae et al. Pediatric Case Report on an Interstitial Lung Disease with a Novel Mutation of SFTPC Successfully Treated with Lung Transplantation // J. Korean. Med. Sci. 2018. May 28; Vol. 33, No. 22. e159. doi: 10.3346/jkms.2018.33.e159.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
