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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ldt</journal-id><journal-title-group><journal-title xml:lang="ru">Лучевая диагностика и терапия</journal-title><trans-title-group xml:lang="en"><trans-title>Diagnostic radiology and radiotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-5343</issn><publisher><publisher-name>Baltic Medical Education Center</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22328/2079-5343-2022-13-1-39-50</article-id><article-id custom-type="elpub" pub-id-type="custom">ldt-696</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Изменения органов желудочно-кишечного тракта при новой коронавирусной инфекции (COVID-19): компьютерно-томографическая семиотика</article-title><trans-title-group xml:lang="en"><trans-title>Changes in the organs of the gastrointestinal tract in a new coronavirus infection (COVID-19): computed tomography semiotics</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3279-6448</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ратникова</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Ratnikova</surname><given-names>A. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник, врач-кардиолог высшей категории приемного отделения;</p><p>главный врач, 197720, Санкт-Петербург, Приморское шоссе 502</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">a.ratnikova@hcresort.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1095-8787</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гриневич</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Grinevich</surname><given-names>V. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий 2 кафедрой (терапии усовершенствования врачей),</p><p>194044, Санкт-Петербург, ул. Академика Лебедева, д. 6</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">grinevich_vb@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9645-8408</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ратников</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ratnikov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заместитель генерального директора-медицинский директор,  194291, Санкт-Петербург, пр. Культуры, д. 4;</p><p>врач-рентгенолог; профессор научно-клинического и  образовательного центра«Лучевая диагностика и ядерная медицина» Института высоких медицинских технологий, 199034, Санкт-Петербург, Университетская наб., д. 7–9</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">dr.ratnikov@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4398-7525</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlov</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, доцент, профессор кафедры инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний),</p><p>194044, Санкт-Петербург, ул. Академика Лебедева, д. 6</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">kosstiak@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Северо-Западный окружной научно-клинический центр имени Л. Г. Соколова Федерального медико-биологического агентства России;&#13;
«Первая Линия», Health Care Resort</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-West District Scientific and Clinical Center named after L. G. Sokolov Federal Medical and Biological Agency;&#13;
«Pervaya Liniya», Health Care Resort</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Военно-медицинская академия имени С. М. Кирова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kirov Military Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Северо-Западный окружной научно-клинический центр имени Л. Г. Соколова Федерального медико-биологического агентства России;&#13;
Санкт-Петербургский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-West District Scientific and Clinical Center named after L. G. Sokolov Federal Medical and Biological Agency;&#13;
St. Petersburg State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>23</day><month>05</month><year>2022</year></pub-date><volume>13</volume><issue>1</issue><fpage>39</fpage><lpage>50</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ратникова А.К., Гриневич В.Б., Ратников В.А., Козлов К.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ратникова А.К., Гриневич В.Б., Ратников В.А., Козлов К.В.</copyright-holder><copyright-holder xml:lang="en">Ratnikova A.K., Grinevich V.B., Ratnikov V.A., Kozlov K.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://radiag.bmoc-spb.ru/jour/article/view/696">https://radiag.bmoc-spb.ru/jour/article/view/696</self-uri><abstract><sec><title>Введение</title><p>Введение. Новая коронавирусная инфекция (COVID-19) представляет собой патогенетически сложное заболевание, отличающееся вовлечением в патологический процесс основных органов и систем человека, в том числе органов желудочнокишечного тракта (ЖКТ).</p></sec><sec><title>Цель</title><p>Цель: изучить гастроэнтерологические проявления COVID-19 у больных легкой и средней степени тяжести на основе анализа данных комплексного, в том числе компьютерно-томографического, обследования.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включены 80 пациентов, госпитализированных с подтвержденным диагнозом COVID-19 (19 больных с легкой степенью и 61 — со средней степенью тяжести), которым выполнено комплексное оригинальное обследование при поступлении в стационар и амбулаторно на 8-й неделе динамического наблюдения. В комплексной терапии 41 больного использован препарат ребамипид. Объем обследования включал анкетирование, традиционные клинические, клинико-лабораторные, биохимические, инструментальные и лучевые исследования, уникальные методики изучения микробиоты и кишечной проницаемости. Всем пациентам также выполнена компьютерная томография (КТ) органов грудной клетки с последующим анализом и  постпроцессорной обработкой изображений верхнего отдела брюшной полости. Также в исследование включена группа из 43 стационарных пациентов со средней степенью тяжести заболевания, в качестве контрольной использована группа из 17 практически здоровых пациентов.</p></sec><sec><title>Результаты и выводы</title><p>Результаты и выводы. Предложена методика качественной и  количественной оценки состояния паренхиматозных и полых органов верхнего отдела брюшной полости по данным КТ. Установлено, что при средней степени тяжести COVID19 количественные критерии (рентгеновская плотность печени, поджелудочной железы, желчи) были подвержены более выраженным отклонениям, как и  диаметр толстой кишки. Дополнительные диагностические возможности стандартного протокола КТ органов грудной клетки у больных СOVID-19 связаны с постпроцессорным анализом изображений органов брюшной полости. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. A new coronavirus infection (COVID-19) is a pathogenetically complex disease characterized by the involvement of the main human organs and systems in the pathological process, including the organs of the gastrointestinal tract (gastrointestinal tract).</p></sec><sec><title>Purpose</title><p>Purpose: to study the gastroenterological manifestations of COVID-19 in patients of mild and moderate severity based on the analysis of complex data, including computed tomography examination.</p></sec><sec><title>Material and methods</title><p>Material and methods. The study included 80 patients hospitalized with a confirmed diagnosis of COVID-19 (19 patients with mild and 61 with moderate severity) who underwent a comprehensive original examination upon admission to the hospital and outpatient at week 8 of dynamic follow-up. In the complex therapy of 41 patients, the drug rebamipid was used. The scope of the examination included questionnaires, traditional clinical, clinical and laboratory, biochemical, instrumental and radiation studies, unique methods for studying microbiota and intestinal permeability. All patients also underwent computed tomography (CT) of the chest organs, followed by analysis and postprocessing of images of the upper abdominal cavity. The study also included a group of 43 inpatient patients with moderate severity of the disease, a group of 17 practically healthy patients was used as a control.</p></sec><sec><title>Results and conclusions</title><p>Results and conclusions. A method of qualitative and quantitative assessment of the state of parenchymal and hollow organs of the upper abdominal cavity according to CT data is proposed. It was found that with moderate severity of COVID-19, quantitative criteria (attenuation coefficient of the liver, pancreas, bile) were subject to more pronounced deviations, as was the diameter of the colon. Additional diagnostic capabilities of the standard chest CT protocol in patients with COVID-19 are associated with postprocessor analysis of images of abdominal organs. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>новая коронавирусная инфекция</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2 компьютерная томография (КТ)</kwd><kwd>постпроцессорный анализ</kwd><kwd>рентгеновская плотность</kwd><kwd>единицы Хаунсфилда (HU)</kwd><kwd>желудочно-кишечный тракт (ЖКТ)</kwd></kwd-group><kwd-group xml:lang="en"><kwd>new coronavirus infection</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>computer tomography (CT)</kwd><kwd>postprocessor analysis</kwd><kwd>attenuation coefficient</kwd><kwd>HU</kwd><kwd>gastrointestinal tract (GIT)</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chang Y.C., Yu C.J., Chang S.C., Galvin J.R., Liu H.-M., Hsiao Ch.-H., Kuo P.-H., Chen K.-Yu., Franks T.J., Huang K.-M., Yang P.-C. 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