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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ldt</journal-id><journal-title-group><journal-title xml:lang="ru">Лучевая диагностика и терапия</journal-title><trans-title-group xml:lang="en"><trans-title>Diagnostic radiology and radiotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-5343</issn><publisher><publisher-name>Baltic Medical Education Center</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22328/2079-5343-2023-14-3-27-38</article-id><article-id custom-type="elpub" pub-id-type="custom">ldt-901</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИИ И ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURES AND REVIEWS</subject></subj-group></article-categories><title-group><article-title>Предпосылки для использования текстурного анализа в дифференциальной диагностике кистозных образований поджелудочной железы: критическая оценка опубликованных метаанализов и рекомендаций международных сообществ</article-title><trans-title-group xml:lang="en"><trans-title>Preconditions for radiomics-based approach in differential diagnosis of pancreatic cystic  lesions: critical evaluation of meta-analyses and international guidelines</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8276-3594</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коваленко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovalenko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коваленко Анастасия Андреевна  — ординатор по  специальности «Рентгенология»  </p><p>117997, Москва, Большая Серпуховская ул., д. 27</p></bio><bio xml:lang="en"><p>Anastasia A. Kovalenko — intern-radiologist of the Rаdiology depаrtment А. V. Vishnevsky Nаtionаl Mediсаl Reseаrсh Сenter of Surgery</p><p>115093, Moscow, ul. Bolshaya Serpukhovskaya, 2</p></bio><email xlink:type="simple">nastua_kovalenko@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9357-0998</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кармазановский</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Karmazanovsky</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кармазановский Григорий Григорьевич — доктор медицинских наук, профессор, академик Российской академии наук, заведующий отделом лучевых методов диагностики и  лечения  Национального медицинского исследовательского центра хирургии имени А. В. Вишневского; профессор кафедры лучевой диагностики и  терапии медико-биологического факультета Российского национального исследовательского медицинского университета имени Н. И. Пирогова</p><p>Национальный медицинский исследовательский центр хирургии имени А. В. Вишневского, 117997, Москва, Большая Серпуховская ул., д. 27</p><p>Российский национальный исследовательский медицинский университет имени Н. И. Пирогова, 117321, Москва, ул. Островитянова, д. 1 </p></bio><bio xml:lang="en"><p>Grigory G. Karmazanovsky — Dr. of Sci. (Med.), Professor, Academician of the Russiаn Асаdemy of Sсienсes, Heаd of the Rаdiology depаrtment А. V. Vishnevsky Nаtionаl Mediсаl Reseаrсh Сenter of Surgery; professor of Radiology department of MBF of Pirogov Russian National Research Medical University</p><p>А. V. Vishnevsky Nаtionаl Mediсаl Reseаrсh Сenter of Surgery, 115093, Moscow, ul. Bolshaya Serpukhovskaya, 27</p></bio><email xlink:type="simple">karmazanovsky@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр хирургии имени А. В. Вишневского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A. V. Vishnevsky Medical Research Center of Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр хирургии имени А. В. Вишневского; Российский национальный исследовательский медицинский университет имени Н. И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A. V. Vishnevsky Medical Research Center of Surgery; Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>04</day><month>10</month><year>2023</year></pub-date><volume>14</volume><issue>3</issue><fpage>27</fpage><lpage>38</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коваленко А.А., Кармазановский Г.Г., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Коваленко А.А., Кармазановский Г.Г.</copyright-holder><copyright-holder xml:lang="en">Kovalenko A.A., Karmazanovsky G.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://radiag.bmoc-spb.ru/jour/article/view/901">https://radiag.bmoc-spb.ru/jour/article/view/901</self-uri><abstract><sec><title>ВВЕДЕНИЕ</title><p>ВВЕДЕНИЕ: Кистозные образования поджелудочной железы (ПЖ) представлены гетерогенной группой доброкачественных и злокачественных изменений, различных по гистологическим, патоморфологическим и прогностическим признакам. Широкое внедрение и  совершенствование методов лучевой диагностики повышает выявляемость кист ПЖ. Несмотря на современные диагностические методики, по-прежнему, актуальна и сложна проблема дифференцировки различных подтипов кист и поиска признаков малигнизации.</p></sec><sec><title>ЦЕЛЬ</title><p>ЦЕЛЬ: Анализ международных публикаций, посвященных возможностям и трудностям дифференцировки кистозных образований ПЖ методами инвазивной и неинвазивной лучевой диагностики, анализ утвержденных рекомендаций по ведению пациентов с данной патологией, выявление предпосылок для использования текстурного анализа изображений в диагностике кистозных образований ПЖ.</p></sec><sec><title>МАТЕРИАЛЫ И  МЕТОДЫ</title><p>МАТЕРИАЛЫ И  МЕТОДЫ: Проведен поиск научных публикаций в  информационно-аналитических системах PubMed и  Springer за  период 2009–2023  гг. по  ключевым словам: «pancreatic tumors» (опухоли ПЖ), «pancreatic cyst» (киста ПЖ), «pancreatic cystic lesion» (кистозное образование ПЖ), «pancreatic radiomics» (радиомика ПЖ), «intraductal papillary mucinous neoplasm» (внутрипротоковая папиллярная муцинозная опухоль), «pancreatic cystadenoma» (цистаденома ПЖ). Для анализа было отобрано 49 публикаций.</p></sec><sec><title>РЕЗУЛЬТАТЫ</title><p>РЕЗУЛЬТАТЫ: Несмотря на  высокий потенциал современных методов неинвазивной диагностики в  обнаружении кист ПЖ, до сих пор представляет большую трудность дифференцировка кистозных образований между собой. Существующим на данный момент руководствам недостает специфичности в дифференцировке кистозных образований, что требует поиска новых маркеров. На данный момент оценка потенциала малигнизации кист ПЖ сводится лишь к двум основным критериям — диаметру главного панкреатического протока (ГПП) и наличию аскуляризированного солидного компонента.</p></sec><sec><title>ЗАКЛЮЧЕНИЕ</title><p>ЗАКЛЮЧЕНИЕ: Схожесть семиотики, ограниченность инвазивных методов диагностики, высокие риски рецидива и потенциала малигнизации при определенных подтипах кистозных неоплазий диктуют необходимость разработки и  внедрения в практику новых диагностических методик, которые позволят более прецизионно оценивать структуру образований, точнее стратифицировать риски и  отдаленный прогноз. Текстурный анализ изображений является новым и  перспективным направлением неинвазивной лучевой диагностики и делает возможным оценку тех структурных параметров образований, суждение о которых невозможно по данным методов лучевой диагностики в их привычном виде, и позволяет в определенной степени нивелировать проблемы традиционного диагностического подхода.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>INTRODUCTION</title><p>INTRODUCTION: Pancreatic cystic lesions (PCLs) are a heterogenous group of lesions ranging from benign to malignant with variable histological, pathomorphological and prognostic characteristics. The development and improvement of radiation methods provides a great opportunity to diagnose such neoplasms. However, there are still difficulties in differential diagnosis and prediction malignant potential in pancreatic cyst subtypes due to their similar radiation characteristics.</p></sec><sec><title>OBJECTIVE</title><p>OBJECTIVE: To determine the diagnostic performane and difficulties of differentiating PCLs by invasive and non-invasive radiological methods. To determine the preconditions for radiomics-based approach in differential diagnosis of pancreatic cystic lesions based on a review and analysis of international guidelines.</p></sec><sec><title>MATERIALS AND METHODS</title><p>MATERIALS AND METHODS: We searched for scientific publications in the PubMed and Springer information and analytical systems for 2009–2023 by keywords: «pancreatic tumors», «pancreatic cyst», «pancreatic cystic lesion», «pancreatic radiomics», «intraductal papillary mucinous neoplasm», «pancreatic cystadenoma». As a result, 49 articles were selected for analysis.</p></sec><sec><title>RESULTS</title><p>RESULTS: Despite the high potential of modern non-invasive radiation methods in the detection of pancreatic cysts, differentiation of PCLs subtypes is still very difficult. Due to the variability of international guidelines and a lack of their specificity, there is no universal consensus for management PCLs. In this regard, introduction new alternative diagnostic methods and markers is an important direction of research. At the moment, the assessment of the malignant potential of PCLs is comes down to only two main signs — the main pancreatic duct diameter and the vascularized solid component.</p></sec><sec><title>CONCLUSION</title><p>CONCLUSION: Currently, common semiotic features, limitations of invasive diagnostic methods and increasing risks of recurrence and malignancy dictate the need to apply new diagnostic approaches to evaluation of PCLs. Searching and introduction new markers will allow us to analyze the lesion structure, to stratify risks and long-term prognosis more accurately. Textural image analysis is a new and promising noninvasive method with high power. This tool plays an important role to estimate those structural parameters which are impossible to judge according to the standard radiologic features, and to offset the problems of traditional diagnostic approach.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>поджелудочная железа</kwd><kwd>кистозная опухоль</kwd><kwd>радиомика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pancreas</kwd><kwd>cystic tumor</kwd><kwd>radiomics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ozaki K., Ikeno H., Kaizaki Y. et al. 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