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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ldt</journal-id><journal-title-group><journal-title xml:lang="ru">Лучевая диагностика и терапия</journal-title><trans-title-group xml:lang="en"><trans-title>Diagnostic radiology and radiotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-5343</issn><publisher><publisher-name>Baltic Medical Education Center</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ldt-96</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАБЛЮДЕНИЕ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICAL CASES</subject></subj-group></article-categories><title-group><article-title>СТАНДАРТЫ ОКАЗАНИЯ МЕДИЦИНСКОЙ ПОМОЩИ ПЕРФУЗИОННОЕ ИССЛЕДОВАНИЕ ГОЛОВНОГО МОЗГА ПРИ ИШЕМИЧЕСКОМ ИНСУЛЬТЕ: АЛГОРИТМЫ ПОЛУЧЕНИЯ И ИНТЕРПРЕТАЦИИ ДАННЫХ</article-title><trans-title-group xml:lang="en"><trans-title>STANDARTS OF MEDICAL CARE CEREBRAL PERFUSION IMAGING IN ISCHEMIC STROKE: ALGORITHMS FOR DATA ACQUISITION AND INTERPRETATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калинин</surname><given-names>Михаил Николаевич</given-names></name><name name-style="western" xml:lang="en"><surname>Kalinin</surname><given-names>M. N.</given-names></name></name-alternatives><email xlink:type="simple">ninilak@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ибатуллин</surname><given-names>Мурат Масгутович</given-names></name><name name-style="western" xml:lang="en"><surname>Ibatullin</surname><given-names>M. M.</given-names></name></name-alternatives><email xlink:type="simple">murat.ibatullin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курадо</surname><given-names>Аделя Тафкилевна</given-names></name><name name-style="western" xml:lang="en"><surname>Curado</surname><given-names>A. T.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хасанова</surname><given-names>Дина Рустемовна</given-names></name><name name-style="western" xml:lang="en"><surname>Khasanova</surname><given-names>D. R.</given-names></name></name-alternatives><email xlink:type="simple">dhasanova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яушева</surname><given-names>Лилия Маратовна</given-names></name><name name-style="western" xml:lang="en"><surname>Iausheva</surname><given-names>L. M.</given-names></name></name-alternatives><email xlink:type="simple">liliya.yausheva@kazansmu.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рахимов</surname><given-names>Ильнур Шавкатович</given-names></name><name name-style="western" xml:lang="en"><surname>Rakhimov</surname><given-names>I. Sh.</given-names></name></name-alternatives><email xlink:type="simple">ilnur.rakhimov@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Казанский ГМУ Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University, Department of Neurology and Neurosurgery for Postgraduate Training; Inter-regional Clinical Diagnostic Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Межрегиональный клинико-диагностический центр</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Inter-regional Clinical Diagnostic Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Елабужский институт (филиал) ФГАОУ ВПО КФУ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yelabuga College of Kazan Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>0</volume><issue>4</issue><fpage>75</fpage><lpage>90</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Калинин М.Н., Ибатуллин М.М., Курадо А.Т., Хасанова Д.Р., Яушева Л.М., Рахимов И.Ш., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Калинин М.Н., Ибатуллин М.М., Курадо А.Т., Хасанова Д.Р., Яушева Л.М., Рахимов И.Ш.</copyright-holder><copyright-holder xml:lang="en">Kalinin M.N., Ibatullin M.M., Curado A.T., Khasanova D.R., Iausheva L.M., Rakhimov I.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://radiag.bmoc-spb.ru/jour/article/view/96">https://radiag.bmoc-spb.ru/jour/article/view/96</self-uri><abstract><p>На основе данных литературы и нашего собственного опыта пошагово описываются алгоритмы получения и интерпретации перфузионных данных при ишемическом инсульте, обсуждаются показания и противопоказания к проведению исследования, показана роль мультимодальных протоколов визуализации в дифференциальной диагностике масок инсульта (воспаление, опухоль, демиелинизация). При анализе перфузионных данных выделены стадии перфузионных нарушений (компенсация, субкомпенсация, декомпенсация) в контексте их локализации (ядро, пенумбра), сделан акцент на феномене люксорной перфузии, представлены прогностические критерии роста ядра инфаркта и возникновения геморрагической трансформации.</p></abstract><trans-abstract xml:lang="en"><p>Based on the literature review and our own experience, algorithms for cerebral perfusion data acquisition and interpretation are outlined in ischemic stroke using a step-by-step approach. Indications and contraindications to the study are also discussed. The role of multimodal brain imaging protocols in distinguishing stroke mimics (inflammation, tumors, demyelination) is emphasized. By analyzing the data, stages of the perfusion disorders (compensation, subcompensation, and decompensation) have been highlighted in the context of their localization (the infarct core, the penumbra). The luxury perfusion phenomenon is stressed, and prognostic criteria for infarct core growth and development of hemorrhagic transformation are given.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>компьютерная томография</kwd><kwd>магнитно-резонансная томография</kwd><kwd>нейровизуализация</kwd><kwd>ишемический инсульт</kwd><kwd>перфузия головного мозга</kwd><kwd>CT</kwd><kwd>MRI</kwd><kwd>brain imaging</kwd><kwd>ischemic stroke</kwd><kwd>cerebral perfusion</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cha S. Perfusion MR imaging: basic principles and clinical applications // Magn. Reson Imaging Clin. N. Am.- 2003.- Vol. 11(3).- Р. 403-413.</mixed-citation><mixed-citation xml:lang="en">Cha S. Perfusion MR imaging: basic principles and clinical applications // Magn. Reson Imaging Clin. N. Am.- 2003.- Vol. 11(3).- Р. 403-413.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Alsop D. C., Detre J. A., Golay X. et al. Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia // Magn. Reson. Med.- 2015.- Vol. 73.- Р. 102-116.</mixed-citation><mixed-citation xml:lang="en">Alsop D. C., Detre J. A., Golay X. et al. Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia // Magn. Reson. Med.- 2015.- Vol. 73.- Р. 102-116.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Olivot J. M., Mlynash M., Zaharchuk G. et al. Perfusion MRI (Tmax and MTT) correlation with xenon CT cerebral blood flow in stroke patients. Neurology.- 2009.- Vol. 72(13).- Р. 1140-1145.</mixed-citation><mixed-citation xml:lang="en">Olivot J. M., Mlynash M., Zaharchuk G. et al. Perfusion MRI (Tmax and MTT) correlation with xenon CT cerebral blood flow in stroke patients. Neurology.- 2009.- Vol. 72(13).- Р. 1140-1145.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Yonas H., Pindzola R. P., Johnson D. W. Xenon/computed tomography cerebral blood flow and its use in clinical management // Neurosurg. Clin. N. Am.- 1996.- Vol. 7 (4).- Р. 605-616.</mixed-citation><mixed-citation xml:lang="en">Yonas H., Pindzola R. P., Johnson D. W. Xenon/computed tomography cerebral blood flow and its use in clinical management // Neurosurg. Clin. N. Am.- 1996.- Vol. 7 (4).- Р. 605-616.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Takahashi S., Tanizaki Y., Kimura H. et al. Comparison of cerebral blood flow data obtained by computed tomography (CT) perfusion with that obtained by xenon CT using 320-row CT // J. Stroke Cerebrovasc. Dis.- 2015.- Vol. 24 (3).- Р. 635-641.</mixed-citation><mixed-citation xml:lang="en">Takahashi S., Tanizaki Y., Kimura H. et al. Comparison of cerebral blood flow data obtained by computed tomography (CT) perfusion with that obtained by xenon CT using 320-row CT // J. Stroke Cerebrovasc. Dis.- 2015.- Vol. 24 (3).- Р. 635-641.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wintermark M., Thiran J. P., Maeder P. et al. Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: a validation study // Am. J. Neuroradiol.- 2001.- Vol. 22(5).- Р. 905-914.</mixed-citation><mixed-citation xml:lang="en">Wintermark M., Thiran J. P., Maeder P. et al. Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: a validation study // Am. J. Neuroradiol.- 2001.- Vol. 22(5).- Р. 905-914.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">ACR-ASNR-SPR practice parameter for the performance of computed tomography (CT) perfusion in neuroradiologic imaging.- 2014.- Р. 1-10.</mixed-citation><mixed-citation xml:lang="en">ACR-ASNR-SPR practice parameter for the performance of computed tomography (CT) perfusion in neuroradiologic imaging.- 2014.- Р. 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">ACR-ASNR-SPR practice parameter for the performance of intracranial magnetic resonance perfusion imaging.- 2014.- Р. 1-8.</mixed-citation><mixed-citation xml:lang="en">ACR-ASNR-SPR practice parameter for the performance of intracranial magnetic resonance perfusion imaging.- 2014.- Р. 1-8.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hoeffner E. G., Case I., Jain R. et al. Cerebral perfusion CT: technique and clinical applications. Radiology.- 200.- Vol. 231 (3).- Р. 632-644.</mixed-citation><mixed-citation xml:lang="en">Hoeffner E. G., Case I., Jain R. et al. Cerebral perfusion CT: technique and clinical applications. Radiology.- 200.- Vol. 231 (3).- Р. 632-644.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Wintermark M., Sincic R., Sridhar D. et al. Cerebral perfusion CT: technique and clinical applications // J. Neuroradiol.- 2008.- Vol. 35(5).- Р. 253-260.</mixed-citation><mixed-citation xml:lang="en">Wintermark M., Sincic R., Sridhar D. et al. Cerebral perfusion CT: technique and clinical applications // J. Neuroradiol.- 2008.- Vol. 35(5).- Р. 253-260.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">stergaard L. Principles of cerebral perfusion imaging by bolus tracking // J. Magn. Reson Imaging.- 2005.- Vol. 22(6).- Р. 710-717.</mixed-citation><mixed-citation xml:lang="en">stergaard L. Principles of cerebral perfusion imaging by bolus tracking // J. Magn. Reson Imaging.- 2005.- Vol. 22(6).- Р. 710-717.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Essig M., Shiroishi M. S., Nguyen T. B. et al. Perfusion MRI: the five most frequently asked technical questions // Am. J. Roentgenol.- 2013.- Vol. 200(1).- Р. 24-34.</mixed-citation><mixed-citation xml:lang="en">Essig M., Shiroishi M. S., Nguyen T. B. et al. Perfusion MRI: the five most frequently asked technical questions // Am. J. Roentgenol.- 2013.- Vol. 200(1).- Р. 24-34.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">O’Connor J. P., Tofts P. S., Miles K. A. et al. Dynamic contrast-enhanced imaging techniques: CT and MRI // Br. J. Radiol. - 2011.- Vol. 84 Spec № 2.- S. 112-120.</mixed-citation><mixed-citation xml:lang="en">O’Connor J. P., Tofts P. S., Miles K. A. et al. Dynamic contrast-enhanced imaging techniques: CT and MRI // Br. J. Radiol. - 2011.- Vol. 84 Spec № 2.- S. 112-120.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Joint Committee for the Procedure Guidelines for CT/MR Perfusion Imaging. Procedure Guidelines for CT/MR Perfusion Imaging 2006 // JCR-JSMRM-ASIST-Japan.- 2006.- Р. 1-29.</mixed-citation><mixed-citation xml:lang="en">Joint Committee for the Procedure Guidelines for CT/MR Perfusion Imaging. Procedure Guidelines for CT/MR Perfusion Imaging 2006 // JCR-JSMRM-ASIST-Japan.- 2006.- Р. 1-29.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rohrer M., Bauer H., Mintorovitch J. et al. Comparison of magnetic properties of MRI contrast media solutions a different magnetic field strengths // Invest Radiol.- 2005.- Vol. 40.- Р. 715-724.</mixed-citation><mixed-citation xml:lang="en">Rohrer M., Bauer H., Mintorovitch J. et al. Comparison of magnetic properties of MRI contrast media solutions a different magnetic field strengths // Invest Radiol.- 2005.- Vol. 40.- Р. 715-724.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts H. C., Roberts T. P., Smith W. S. et al. Multisection dynamic CT perfusion for acute cerebral ischemia: the «toggling-table” technique // Am. J. Neuroradiol.- 2001.- Vol. 22(6).- Р. 1077-1080.</mixed-citation><mixed-citation xml:lang="en">Roberts H. C., Roberts T. P., Smith W. S. et al. Multisection dynamic CT perfusion for acute cerebral ischemia: the «toggling-table” technique // Am. J. Neuroradiol.- 2001.- Vol. 22(6).- Р. 1077-1080.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Youn S. W., Kim J. H., Weon Y. C. et al. Perfusion CT of the brain using 40-mm-wide detector and toggling table technique for initial imaging of acute stroke // Am. J. Roentgenol.- 2008.- Vol. 191 (3).- Р. W120-126.</mixed-citation><mixed-citation xml:lang="en">Youn S. W., Kim J. H., Weon Y. C. et al. Perfusion CT of the brain using 40-mm-wide detector and toggling table technique for initial imaging of acute stroke // Am. J. Roentgenol.- 2008.- Vol. 191 (3).- Р. W120-126.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Claise B., Gabrillargues J., Chabert E. et al. Advanced Neuroimaging with Computed Tomography Scanning. Theory and Applications of CT Imaging and Analysis / ed. by N. Homma // InTech.- 2011.- Vol. 213-232.</mixed-citation><mixed-citation xml:lang="en">Claise B., Gabrillargues J., Chabert E. et al. Advanced Neuroimaging with Computed Tomography Scanning. Theory and Applications of CT Imaging and Analysis / ed. by N. Homma // InTech.- 2011.- Vol. 213-232.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">de Lucas E. M., Sànchez E., Gutiérrez A. et al. CT protocol for acute stroke: tips and tricks for general radiologists // Radiographics.- 2008.- Vol. 28(6).- Р. 1673-1687.</mixed-citation><mixed-citation xml:lang="en">de Lucas E. M., Sànchez E., Gutiérrez A. et al. CT protocol for acute stroke: tips and tricks for general radiologists // Radiographics.- 2008.- Vol. 28(6).- Р. 1673-1687.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Liebeskind D. S., Alexandrov A. V Advanced multimodal CT/MRI approaches to hyperacute stroke diagnosis, treatment, and monitoring // Ann. N. Y. Acad. Sci.- 2012.- Vol. 1268.- Р. 1-7.</mixed-citation><mixed-citation xml:lang="en">Liebeskind D. S., Alexandrov A. V Advanced multimodal CT/MRI approaches to hyperacute stroke diagnosis, treatment, and monitoring // Ann. N. Y. Acad. Sci.- 2012.- Vol. 1268.- Р. 1-7.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Chavhan G. B., Babyn P. S., Thomas B. et al. Principles, techniques, and applications of T2*-based MR imaging and its special applications // Radiographics.- 2009.- Vol. 29 (5).- Р. 1433-1449.</mixed-citation><mixed-citation xml:lang="en">Chavhan G. B., Babyn P. S., Thomas B. et al. Principles, techniques, and applications of T2*-based MR imaging and its special applications // Radiographics.- 2009.- Vol. 29 (5).- Р. 1433-1449.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts H. C., Roberts T. P., Brasch R. C. et al. Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: correlation with histologic grade // Am. J. Neuroradiol.- 2000.- Vol. 21 (5).- Р. 891-899.</mixed-citation><mixed-citation xml:lang="en">Roberts H. C., Roberts T. P., Brasch R. C. et al. Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: correlation with histologic grade // Am. J. Neuroradiol.- 2000.- Vol. 21 (5).- Р. 891-899.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Jain R., Ellika S. K., Scarpace L. et al. Quantitative estimation of permeability surface-area product in astroglial brain tumors using perfusion CT and correlation with histopathologic grade // Am. J. Neuroradiol.- 2008.- Vol. 29 (4).- Р. 694-700.</mixed-citation><mixed-citation xml:lang="en">Jain R., Ellika S. K., Scarpace L. et al. Quantitative estimation of permeability surface-area product in astroglial brain tumors using perfusion CT and correlation with histopathologic grade // Am. J. Neuroradiol.- 2008.- Vol. 29 (4).- Р. 694-700.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen G. T., Coulthard A., Wong A. et al. Measurement of blood-brain barrier permeability in acute ischemic stroke using standard first-pass perfusion CT data // Neuroimage Clin.- 2013.- Vol. 22, № 2.- Р. 658-662.</mixed-citation><mixed-citation xml:lang="en">Nguyen G. T., Coulthard A., Wong A. et al. Measurement of blood-brain barrier permeability in acute ischemic stroke using standard first-pass perfusion CT data // Neuroimage Clin.- 2013.- Vol. 22, № 2.- Р. 658-662.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Lupo J. M., Cha S., Chang S. M. et al. Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity // Am. J. Neuroradiol.- 2005.- Vol. 26(6).- Р. 1446-1454.</mixed-citation><mixed-citation xml:lang="en">Lupo J. M., Cha S., Chang S. M. et al. Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity // Am. J. Neuroradiol.- 2005.- Vol. 26(6).- Р. 1446-1454.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Saunders D. E. MR spectroscopy in stroke // Brit. Med Bull.- 2000.- Vol. 56 (2).- Р. 334-345.</mixed-citation><mixed-citation xml:lang="en">Saunders D. E. MR spectroscopy in stroke // Brit. Med Bull.- 2000.- Vol. 56 (2).- Р. 334-345.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Leclercq D., Trunet S., Bertrand A. et al. Cerebral tumor or pseudotumor? // Diagn Interv Imaging.- 2014.- Vol. 95(10).- Р. 906-916.</mixed-citation><mixed-citation xml:lang="en">Leclercq D., Trunet S., Bertrand A. et al. Cerebral tumor or pseudotumor? // Diagn Interv Imaging.- 2014.- Vol. 95(10).- Р. 906-916.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Bivard A., Levi C., Spratt N. et al. Perfusion CT in acute stroke: a comprehensive analysis of infarct and penumbra. Radiology.- 2013.- Vol. 267 (2).- Р. 543-550.</mixed-citation><mixed-citation xml:lang="en">Bivard A., Levi C., Spratt N. et al. Perfusion CT in acute stroke: a comprehensive analysis of infarct and penumbra. Radiology.- 2013.- Vol. 267 (2).- Р. 543-550.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Abels B., Villablanca J. P., Tomand B. F et al. Acute stroke: a comparison of different CT perfusion algorithms and validation of ischaemic lesions by follow-up imaging // Eur. Radiol.- 2012.- Vol. 22(12).- Р. 2559-2567.</mixed-citation><mixed-citation xml:lang="en">Abels B., Villablanca J. P., Tomand B. F et al. Acute stroke: a comparison of different CT perfusion algorithms and validation of ischaemic lesions by follow-up imaging // Eur. Radiol.- 2012.- Vol. 22(12).- Р. 2559-2567.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Patil V., Johnson G. An improved model for describing the contrast bolus in perfusion MRI // Med Phys.- 2011.- Vol. 38 (12).- Р. 6380-6383.</mixed-citation><mixed-citation xml:lang="en">Patil V., Johnson G. An improved model for describing the contrast bolus in perfusion MRI // Med Phys.- 2011.- Vol. 38 (12).- Р. 6380-6383.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Calamante F., Christensen S., Desmond P. M. et al. The physiological significance of the time-to-maximum (Tmax) parameter in perfusion MRI // Stroke. - 2010.- Vol. 41(6).- Р. 1169-1174.</mixed-citation><mixed-citation xml:lang="en">Calamante F., Christensen S., Desmond P. M. et al. The physiological significance of the time-to-maximum (Tmax) parameter in perfusion MRI // Stroke. - 2010.- Vol. 41(6).- Р. 1169-1174.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Lui Y. W., Tang E. R., Allmendinger A. M. et al. Evaluation of CT perfusion in the setting of cerebral ischemia: patterns and pitfalls // Am. J. Neuroradiol.- 2010.- Vol. 31 (9).- Р. 1552-1563.</mixed-citation><mixed-citation xml:lang="en">Lui Y. W., Tang E. R., Allmendinger A. M. et al. Evaluation of CT perfusion in the setting of cerebral ischemia: patterns and pitfalls // Am. J. Neuroradiol.- 2010.- Vol. 31 (9).- Р. 1552-1563.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Kudo K., Terae S., Katoh C. et al. Quantitative cerebral blood flow measurement with dynamic perfusion CT using the vascular-pixel elimination method: comparison with H2(15)O positron emission tomography // Am. J. Neuroradiol.- 2003.- Vol. 24 (3).- Р. 419-426.</mixed-citation><mixed-citation xml:lang="en">Kudo K., Terae S., Katoh C. et al. Quantitative cerebral blood flow measurement with dynamic perfusion CT using the vascular-pixel elimination method: comparison with H2(15)O positron emission tomography // Am. J. Neuroradiol.- 2003.- Vol. 24 (3).- Р. 419-426.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Wintermark M., Flanders A. E., Velthuis B. et al. Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke.- 2006.- Vol. 37 (4).- Р. 979-985.</mixed-citation><mixed-citation xml:lang="en">Wintermark M., Flanders A. E., Velthuis B. et al. Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke.- 2006.- Vol. 37 (4).- Р. 979-985.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Schaefer P. W., Roccatagliata L., Ledezma C. et al. First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy // Am. J. Neuroradiol.- 2006.- Vol. 27 (1).- Р. 20-25.</mixed-citation><mixed-citation xml:lang="en">Schaefer P. W., Roccatagliata L., Ledezma C. et al. First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy // Am. J. Neuroradiol.- 2006.- Vol. 27 (1).- Р. 20-25.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Engelter S. T., Provenzale J. M., Petrella J. R. et al. Use of exponential diffusion imaging to determine the age of ischemic infarcts // J. Neuroimaging.- 2001.- Vol. 11 (2).- Р. 141-147.</mixed-citation><mixed-citation xml:lang="en">Engelter S. T., Provenzale J. M., Petrella J. R. et al. Use of exponential diffusion imaging to determine the age of ischemic infarcts // J. Neuroimaging.- 2001.- Vol. 11 (2).- Р. 141-147.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Forkert N. D., Kaesemann P., Treszl A. et al. Comparison of 10 TTP and Tmax estimation techniques for MR perfusion-diffusion mismatch quantification in acute stroke // Am. J. Neuroradiol.- 2013.- Vol. 34(9).- Р. 1697-1703.</mixed-citation><mixed-citation xml:lang="en">Forkert N. D., Kaesemann P., Treszl A. et al. Comparison of 10 TTP and Tmax estimation techniques for MR perfusion-diffusion mismatch quantification in acute stroke // Am. J. Neuroradiol.- 2013.- Vol. 34(9).- Р. 1697-1703.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Singer O. C., Humpich M. C., Fiehler J. et al. Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging // Ann. Neurol.- 2008.- Vol. 63 (1).- Р. 52-60.</mixed-citation><mixed-citation xml:lang="en">Singer O. C., Humpich M. C., Fiehler J. et al. Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging // Ann. Neurol.- 2008.- Vol. 63 (1).- Р. 52-60.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Hacke W., Albers G., Al-Rawi Y. et al. The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase // Stroke. - 2005.- Vol. 36(1).- Р. 66-73.</mixed-citation><mixed-citation xml:lang="en">Hacke W., Albers G., Al-Rawi Y. et al. The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase // Stroke. - 2005.- Vol. 36(1).- Р. 66-73.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Nagakane Y., Christensen S., Brekenfeld C. et al. EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration // Stroke.- 2011.- Vol. 42(1).- Р. 59-64.</mixed-citation><mixed-citation xml:lang="en">Nagakane Y., Christensen S., Brekenfeld C. et al. EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration // Stroke.- 2011.- Vol. 42(1).- Р. 59-64.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Chen F., Ni Y. C. Magnetic resonance diffusion-perfusion mismatch in acute ischemic stroke: An update // World J Radiol.- 2012.- Vol. 4(3).- Р. 63-74.</mixed-citation><mixed-citation xml:lang="en">Chen F., Ni Y. C. Magnetic resonance diffusion-perfusion mismatch in acute ischemic stroke: An update // World J Radiol.- 2012.- Vol. 4(3).- Р. 63-74.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Powers W. J. Cerebral hemodynamics in ischemic cerebrovascular disease // Ann. Neurol.- 1991.- Vol. 29 (3).- Р. 231-240.</mixed-citation><mixed-citation xml:lang="en">Powers W. J. Cerebral hemodynamics in ischemic cerebrovascular disease // Ann. Neurol.- 1991.- Vol. 29 (3).- Р. 231-240.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Tsivgoulis G., Alexandrov A. V. Cerebral hemodynamics in acute stroke: pathophysiology and clinical implications // J. Vasc. Interv. Neurol.- 2008.- Vol. 1 (3).- Р. 65-69.</mixed-citation><mixed-citation xml:lang="en">Tsivgoulis G., Alexandrov A. V. Cerebral hemodynamics in acute stroke: pathophysiology and clinical implications // J. Vasc. Interv. Neurol.- 2008.- Vol. 1 (3).- Р. 65-69.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Gasparotti R., Grassi M., Mardighian D. et al. Perfusion CT in patients with acute ischemic stroke treated with intra-arterial thrombolysis: predictive value of infarct core size on clinical outcome // Am. J. Neuroradiol.- 2009.- Vol. 30 (4).- Р. 722-727. _№4(6)2015</mixed-citation><mixed-citation xml:lang="en">Gasparotti R., Grassi M., Mardighian D. et al. Perfusion CT in patients with acute ischemic stroke treated with intra-arterial thrombolysis: predictive value of infarct core size on clinical outcome // Am. J. Neuroradiol.- 2009.- Vol. 30 (4).- Р. 722-727. _№4(6)2015</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Best A. C., Acosta N. R., Fraser J. E. et al. Recognizing false ischemic penumbras in CT brain perfusion studies // Radiographics.- 2012.- Vol. 32(4).- Р. 1179-1196.</mixed-citation><mixed-citation xml:lang="en">Best A. C., Acosta N. R., Fraser J. E. et al. Recognizing false ischemic penumbras in CT brain perfusion studies // Radiographics.- 2012.- Vol. 32(4).- Р. 1179-1196.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma V. K., Teoh H. L., Paliwal P. R. et al. Reversed Robin Hood syndrome in a patient with luxury perfusion after acute ischemic stroke // Circulation.- 2011.- Vol. 123 (7).- Р. e243-244.</mixed-citation><mixed-citation xml:lang="en">Sharma V. K., Teoh H. L., Paliwal P. R. et al. Reversed Robin Hood syndrome in a patient with luxury perfusion after acute ischemic stroke // Circulation.- 2011.- Vol. 123 (7).- Р. e243-244.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Suh H. I., Lee S. W., Eom Y. I. et al. A case of delayed neurological recovery with luxury perfusion and a high intracranial arterial calcification burden // J. Stroke.- 2014.- Vol. 16 (1).- Р. 51-53.</mixed-citation><mixed-citation xml:lang="en">Suh H. I., Lee S. W., Eom Y. I. et al. A case of delayed neurological recovery with luxury perfusion and a high intracranial arterial calcification burden // J. Stroke.- 2014.- Vol. 16 (1).- Р. 51-53.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Morelli N., Morelli J., Rota E. et al. CT perfusion mismatch in subacute stroke: oligemia or luxury perfusion? Response to persistent benign oligemia causes ct perfusion mismatch in patients with intracranial large artery occlusive disease during subacute stroke // CNS Neurosci Ther.- 2013.- Vol. 19 (11).- Р. 914-915.</mixed-citation><mixed-citation xml:lang="en">Morelli N., Morelli J., Rota E. et al. CT perfusion mismatch in subacute stroke: oligemia or luxury perfusion? Response to persistent benign oligemia causes ct perfusion mismatch in patients with intracranial large artery occlusive disease during subacute stroke // CNS Neurosci Ther.- 2013.- Vol. 19 (11).- Р. 914-915.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Marchal G., Young A. R., Baron J. C. Early postischemic hyperperfusion: pathophysiologic insights from positron emission tomography // J. Cereb. Blood Flow Metab.- 1999.- Vol. 19 (5).- Р. 467-482.</mixed-citation><mixed-citation xml:lang="en">Marchal G., Young A. R., Baron J. C. Early postischemic hyperperfusion: pathophysiologic insights from positron emission tomography // J. Cereb. Blood Flow Metab.- 1999.- Vol. 19 (5).- Р. 467-482.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Li J. J., Chen X. Y., Soo Y. et al. Persistent benign oligemia causes CT perfusion mismatch in patients with intracranial large artery occlusive disease during subacute stroke // CNS Neurosci Ther.- 2013.- Vol. 19 (8).- Р. 635-637.</mixed-citation><mixed-citation xml:lang="en">Li J. J., Chen X. Y., Soo Y. et al. Persistent benign oligemia causes CT perfusion mismatch in patients with intracranial large artery occlusive disease during subacute stroke // CNS Neurosci Ther.- 2013.- Vol. 19 (8).- Р. 635-637.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Van Seeters T., Biessels G. J., van der Schaaf I. C. et al. Prediction of outcome in patients with suspected acute ischaemic stroke with CT perfusion and CT angiography: the Dutch acute stroke trial (DUST) study protocol // BMC Neurol.- 2014.- Vol. 14.- Р. 37.</mixed-citation><mixed-citation xml:lang="en">Van Seeters T., Biessels G. J., van der Schaaf I. C. et al. Prediction of outcome in patients with suspected acute ischaemic stroke with CT perfusion and CT angiography: the Dutch acute stroke trial (DUST) study protocol // BMC Neurol.- 2014.- Vol. 14.- Р. 37.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann A., Zhu G., Wintermark M. Advanced neuroimaging in stroke patients: prediction of tissue fate and hemorrhagic transformation // Expert Rev. Cardiovasc Ther.- 2012.- Vol. 10 (4).- Р 515-524.</mixed-citation><mixed-citation xml:lang="en">Hoffmann A., Zhu G., Wintermark M. Advanced neuroimaging in stroke patients: prediction of tissue fate and hemorrhagic transformation // Expert Rev. Cardiovasc Ther.- 2012.- Vol. 10 (4).- Р 515-524.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
