ldtЛучевая диагностика и терапияDiagnostic radiology and radiotherapy2079-5343Baltic Medical Education Center10.22328/2079-5343-2024-15-1-15-21ldt-969Research ArticleЛЕКЦИИ И ОБЗОРЫLECTURES AND REVIEWSРадиогеномика при раке молочной железы: обзорRadiogenomics in breast cancer: a reviewhttps://orcid.org/0009-0001-8193-6657ГаранинаА. Э.GaraninaA. E.

Гаранина Анна Эдуардовна — аспирант кафедры лучевой диагностики;  врач ультразвуковой диагностики 

ул. Кирочная, д.41, Санкт-Петербург

Московский пр. 22, Санкт-Петербург

Anna E. Garanina — Postgraduate Student, Department of Radiation Diagnostics; Doctor of Ultrasound Diagnostics

41 Kirochnaya str., St. Petersburg

22 Moskovsky Prospekt, St. Petersburg

anna.garanina.90@mail.ruhttps://orcid.org/0000-0001-8227-1530ХолинА. В.KholinA. V.

Холин Александр Васильевич — доктор медицинских наук, профессор заведующий кафедрой лучевой диагностики 

ул. Кирочная, д.41, Санкт-Петербург

Alexander V. Kholin — Dr. of Sci. (Med.), Professor, Head of the Department of Radiation Diagnostics

41 Kirochnaya str., St. Petersburg

   

holin1959@list.ruСеверо-Западный государственный медицинский университет имени И.И.Мечникова; Клиника СМТ АО Поликлинический комплексРоссияNorth-Western State Medical University named after I.I.Mechnikov; SMT Clinic JSC Polyclinic ComplexRussian FederationСеверо-Западный государственный медицинский университет имени И.И.МечниковаРоссияNorth-Western State Medical University named after I.I.MechnikovRussian Federation2024090420241511521Copyright © Гаранина А.Э., Холин А.В., 20242024Гаранина А.Э., Холин А.В.Garanina A.E., Kholin A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://radiag.bmoc-spb.ru/jour/article/view/969ВВЕДЕНИЕ

ВВЕДЕНИЕ: Раннее выявление рака молочной железы имеет большое значение в диагностике и лечении данного заболевания. Иммуногистохимическое исследование трепан-биоптатов и удаленных хирургических образцов способствовало определению молекулярных маркеров. В настоящее время внимание исследователей привлекают анатомические и функциональные особенности опухолевой ткани, полученные с помощью визуализационных методов. Корреляция конкретных фенотипов на основе изображений (радиомика) с крупномасштабным геномным анализом (геномика) является новой областью исследований, называемой «радиогеномикой» или, точнее, «геномикой изображений». В этой новой области рассматривается связь между методами диагностики и геномными данными, а также с другой клинически значимой информацией.

ЦЕЛЬ

ЦЕЛЬ: Провести анализ на основании данных литературы актуальных тенденций развития радиогеномики при изучении рака молочной железы.

МАТЕРИАЛЫ И МЕТОДЫ

МАТЕРИАЛЫ И МЕТОДЫ: Проведен поиск медицинской литературы с использованием информационно-аналитических баз данных Cochrane, Medline, Elibrary по текстовым поисковым запросам «радиогеномика рака молочной железы», «маммография и радиогеномика», «магнитно-резонансная томография и радиогеномика», «ультразвуковая радиогеномика».

РЕЗУЛЬТАТЫ

РЕЗУЛЬТАТЫ: В результате проведенного исследования обнаружили убедительные доказательства того, что существует умеренная связь между характеристиками визуализации и геномными характеристиками рака молочной железы. Однако полученные результаты имеют ряд ограничительных факторов, искажающих общую картину.

ЗАКЛЮЧЕНИЕ

ЗАКЛЮЧЕНИЕ: Прецизионная медицина может быть оптимизирована с учетом генотипических и фенотипических характеристик опухоли. Однако для развития этого направления требуются новые исследования и развитие баз данных с применением многоцентрового подхода.

INTRODUCTION

INTRODUCTION: Early detection of breast cancer is essential in the diagnosis and treatment of this disease. The results of core biopsy, immunohistochemical methods or removed surgical specimens contributed to the identification of molecular markers. Currently, the attention of researchers is attracted by the anatomical and functional features of tumor tissue obtained using imaging methods. The correlation of specific phenotypes based on images (radiomics) with large-scale genomic analysis (genomics) is a new field of research called “radiogenomics” or, more precisely, “image genomics”. This new field examines the relationship between diagnostic methods and gene data, as well as with other clinically relevant information.

OBJECTIVE

OBJECTIVE: To analyze current trends in the development of radiogenomics in the study of breast cancer based on the literature data.

MATERIALS AND METHODS

MATERIALS AND METHODS: The medical literature was searched using information and analytical databases Cochrane, Medline, and Elibrary using the text search queries “radiogenomics of breast cancer”, “mammography and radiogenomics”, “magnetic resonance imaging and radiogenomics”, “ultrasonic radiogenomics”.

RESULTS

RESULTS: We found strong evidence that there is a moderate relationship between imaging characteristics and genomic characteristics of breast cancer. However, the results obtained have a number of limiting factors that distort the overall picture.

CONCLUSION

CONCLUSION: Precision medicine can be optimized based on the genotypic and phenotypic characteristics of the tumor. However, the development of this direction requires new research and the development of databases using a multicenter approach.

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The authors declare that there are no conflicts of interest present.