THE EFFECT LOW LEVEL LASER THERAPY FOR MANAGEMENT OF RADIATION-INDUCEED MUCOSITIS

Low-level laser therapy as a method for correcting the mucositis caused by ionizing radiation of the oral mucosa is used in clinical practice for various exposure parameters: radiation power not less than 10 mW, laser doses not less than 2 J/cm2. The purpose of this study was to compare the efficacy of low-level laser therapyred and infrared laser radiation for the correction of mucositis of the oral mucosa in patients receiving radiation and chemoradiotherapy for oral and pharyngeal cancer, with laser doses of less than 1 J/cm2. The study included 106 patients who received radiation and chemoradiotherapy for cancer of the oral cavity and pharynx, which were randomly divided into three groups. In the first (37 patients), mucositis was prevented and corrected in accordance with the standards of the clinic, in the second (36 patients) and the third (33 patients), patients were additionally exposed to the oral cavity with Low-level laser therapy (LLLT) at 635 nm and 780 nm at powers of 5 mW and 20 mW, respectively. The effect of LLLT on the wavelength of 635 nm significantly reduced the frequency and severity of mucositis, increased the time until the appearance of the first symptoms of mucositis of the oral mucosa, shortened the duration of severe mucositis (grade 3), and reduced the need for painkillers, including narcotic analgesics compared with the group who received standard prophylaxis and correction of mucositis.

radiation induced mucositis, oral and pharyngeal cancer, low level laser therapy, (chemo) radiation therapy, quality of life

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