DTI FOR DIAGNOSING HYPOXICISCHEMIC BRAIN INJURE IN PRETERM NEONATES

The perinatal lesions of the nervous system in newborns include a number of diseases of the brain, spinal cord and peripheral nerves, united in a group by the time of exposure to damaging factors. The MRI is recognized as the most infor mative and specific method for the diagnosis of perinatal lesions of the central nervous system. By using the MRI, it is possible not only to identify structural changes in the brain, but also to qualitatively assess the myelination of cerebral structures in preterm infants. It was shown that in severe hypoxic-ischemic damage in preterm infants, dysmyelination is more often determined in the posterior pedicle of the inner capsule. DTI is a promising method to quantify the degree of myelination of the brain, visualize pathways, assess their structure and integrity. The aim of the study was to identify significant differences in diffusion values according to DTI in preterm infants with severe hypoxic-ischemic brain injures in the form of periventricular leucomalatia and peri-intraventricular hemorrhage. Methods: Group 1 (10 children) consisted of patients who did not have structural changes on MRI. Group 2 (8 children) consisted of children with periventricular leukomalacia. Group 3 (4 children) consisted of children with peri-intraventricular hemorrhages. The patients was underwent MRI, diffusion-tensor MRI. A comparison was made of the diffusion values in the posterior limb of inner capsules and the thalami between the groups. Results: there were revealed changes in diffusion values, indicating a delay of myelination at the level of the posterior legs of the inner capsules in children with severe hypoxic-ischemic brain injures.

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