Detection of excess sodium in the myocardium under conditions of sodium loading using dual-energy computed tomography
https://doi.org/10.22328/2079-5343-2020-11-1-52-58
Abstract
Introduction. The direct relationship between the level of sodium intake, arterial hypertension, followed by the development of heart failure, a hypothesis of the direct influence of excessive sodium accumulation in myocardial glycosaminoglycans seems quite probable, which can further contribute to the occurrence of diastolic dysfunction and heart failure.The aim of the study was to identify excess sodium in rats under conditions of sodium loading, in comparison with rats at a normal level of sodium intake. Materials and methods. Ten male Wistar rats with the same body weight were divided into two groups: the excess salt intake group and the normal salt intake group. Estimation of the amount of Na and NaCl in the animal myocardium was performed using dual energy computed tomography (DECT) samples. Samples were scanned on a Revolution GSI tomograph (GE Healthcare). For statistical processing of the obtained data, the R language was used. Results. The results of the study showed that the accumulation of Na and NaCl does not depend on the average level of animal feed intake, there is no correlation between weight and accumulation of excess Na in tissues, the level of Na and NaCl detected in myocardial tissue significantly increases the likelihood of a high salt diet in rats, and a relationship between the content Na in the myocardium and NaCl+H2O. Conclusion. The experiment confirmed the existence of a reliable relationship between the sodium compounds calculated on the basis of DECT and the content of these compounds in the samples. The small number of samples did not allow us to calculate normalized rats, but we noted a clear difference between the control group and the high sodium diet.
About the Authors
D. O. Dragunov
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Dmitriy O. Dragunov
Moscow
E. S. Pershina
City Clinical Hospital No. 1 named after N. I. Pirogov
Russian Federation
Russian Federation
Ecatherina S. Pershina
Moscow
A. V. Sokolova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Anna V. Sokolova
Moscow
M. F. Proskurina
Department of Computed Tomography, GE Healthcare
Russian Federation
Russian Federation
Marina F. Proskurina
Moscow
G. P. Arutyunov
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Gregory P. Arutyunov
Moscow
V. M. Mitrokhin
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Vadim M. Mitrokhin
Moscow
References
1. Laffer C.L. et al. Hemodynamics and Salt-and-Water Balance Link Sodium Storage and Vascular Dysfunction in Salt-Sensitive SubjectsNovelty and Significance // Hypertension. 2016. Vol. 68, No. 1. P. 195–203. doi: 10.1161/HYPERTENSIONAHA.116.07289.
2. Arutyunov G.P. et al. The effect of the level of total sodium deposited in the myocardium on its stiffness. Therapeutic Archive, 2017, Vol. 89, No. 1, рр. 32–37 (In Russ.) doi: 10.17116/terarkh201789132-37.
3. Oh Y.S. et al. National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness // Hypertension. 2016. Vol. 68, No. 2. P. 281–288. doi: 10.1161/HYPERTENSIONAHA.116.07415
4. Kwon T.-H. et al. Regulation of collecting duct AQP3 expression: response to mineralocorticoid // Am. J. Physiol.— Ren. Physiol. 2002. Vol. 283, No. 6. P. F1403–F1421. doi: 10.1152/ajprenal.00059.2002
5. Kim G.-H. et al. The thiazide-sensitive Na–Cl cotransporter is an aldosteroneinduced protein // Proc. Natl. Acad. Sci. U. S. A. 1998. Vol. 95, No. 24. P. 14552–14557.
6. Patten R.D., Hall-Porter M.R. Small Animal Models of Heart Failure Development of Novel Therapies, Past and Present // Circ. Heart Fail. 2009. Vol. 2, No. 2. P. 138–144. doi: 10.1161/CIRCHEARTFAILURE.108.839761
7. Karçaaltıncaba M., Aktaş A. Dual-energy CT revisited with multidetector CT: review of principles and clinical applications // Diagn. Interv. Radiol. Ank. Turk. 2011. Vol. 17, No. 3. P. 181–194. doi:10.4261/1305-3825.DIR.3860–10.0
8. Siegel M.J. et al. White Paper of the Society of Computed Body Tomography and Magnetic Resonance on Dual-Energy CT, Part 1: Technology and Terminology // J. Comput. Assist. Tomogr. 2016. Vol. 40, No. 6. P. 841–845. doi: 10.1097/RCT.0000000000000531.
9. Foley W.D. et al. White Paper of the Society of Computed Body Tomography and Magnetic Resonance on Dual-Energy CT, Part 2: Radiation Dose and Iodine Sensitivity // J. Comput. Assist. Tomogr. 2016. Vol. 40, No. 6. P. 846–850. doi: 10.1097/RCT.0000000000000539
10. De Cecco C.N. et al. White Paper of the Society of Computed Body Tomography and Magnetic Resonance on Dual-Energy CT, Part 3: Vascular, Cardiac, Pulmonary, and Musculoskeletal Applications // J. Comput. Assist. Tomogr. 2017. Vol. 41, No. 1. P. 1–7. doi: 10.1097/RCT.0000000000000538
11. Biondi M. et al. Water/cortical bone decomposition: A new approach in dual energy CT imaging for bone marrow oedema detection. A feasibility study // Phys. Medica PM Int. J. Devoted Appl. Phys. Med. Biol. Off. J. Ital. Assoc. Biomed. Phys. AIFB. 2016. Vol. 32, No. 12. P. 1712–1716. doi: 10.1016/j.ejmp.2016.08.004.
12. Goo H.W., Goo J.M. Dual-Energy CT: New Horizon in Medical Imaging // Korean J. Radiol. 2017. Vol. 18, No 4. P. 555–569. doi: 10.3348/kjr.2017.18.4.555.
13. Hawkes D.J., Jackson D.F., Parker R.P. Tissue analysis by dual-energy computed tomography // Br. J. Radiol. 1986. Vol. 59, No. 702. P. 537–542. doi: 10.1259/0007-1285-59-702-537.
14. Patino M. et al. Material Separation Using Dual-Energy CT: Current and Emerging Applications // Radiogr. Rev. Publ. Radiol. Soc. N. Am. Inc. 2016. Vol. 36, No. 4. P. 1087–1105. doi: 10.1148/rg.2016150220.
15. Artz N.S. et al. Quantification of hepatic steatosis with dual-energy computed tomography: comparison with tissue reference standards and quantitative magnetic resonance imaging in the ob/ob mouse // Invest. Radiol. 2012. Vol. 47, No. 10. P. 603–610. doi: 10.1097/RLI.0b013e318261fad0.
16. Morgan D.E. et al. Differentiation of high lipid content from low lipid content adrenal lesions using single-source rapid kilovolt (peak)-switching dual-energy multidetector CT // J. Comput. Assist. Tomogr. 2013. Vol. 37, No. 6. P. 937–943. doi: 10.1097/RCT.0b013e3182aaf996.
17. Mileto A. et al. Dual-energy multidetector CT for the characterization of incidental adrenal nodules: diagnostic performance of contrast-enhanced material density analysis // Radiology. 2015. Vol. 274, No. 2. P. 445–454. doi: 10.1148/radiol.14140876.
Review
For citations:
Dragunov D.O., Pershina E.S., Sokolova A.V., Proskurina M.F., Arutyunov G.P., Mitrokhin V.M. Detection of excess sodium in the myocardium under conditions of sodium loading using dual-energy computed tomography. Diagnostic radiology and radiotherapy. 2020;11(1):52-58. (In Russ.) https://doi.org/10.22328/2079-5343-2020-11-1-52-58
Views:
624
Email this article 