DIFFERENTIAL DIAGNOSIS OF MEDIASTINAL LYMPHADENOPATHY IN LYMPHOMA AND SARCOIDOSIS USING DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING
A. V. Sudarkina,
A. P. Dergilev,
V. V. Kozlov,
Yu. A. Fokina,
I. P. Klimova,
N. A. Gorbunov,
K. V. Shalygin https://doi.org/10.22328/2079-5343-2020-11-3-56-62
Abstract
The aim of the study. Investigation of the potential of diffusion-weighted magnetic resonance imaging (DW-MRI) with apparent diffusion coefficient (ADC) evaluation for differential diagnosis of mediastinal lymphadenopathy in lymphoma and sarcoidosis.
Materials and methods. The study included 15 patients with sarcoidosis and 7 patients with lymphoma. In each patient ADC values of 3 largest lymph nodes were measured.
Results. Differences of mean ADC values in lymphoma (1,01±0,3×10-3mm2/s) and sarcoidosis (1,51±0,25×10-3mm2/s) were significant, p<0,0001. Optimal cut-point value for ADC of ≤1,1×10-3mm2/s differentiated lymphoma from sarcoidosis with sensitivity of 76,2%, specificity of 97,8% and accuracy of 90,9%, the area under the ROC-curve was 0,89.
Conclusion. Preliminary results of the study have demonstrated the potential of DW-MRI in differential diagnosis of lymphoma and sarcoidosis and expediency of the further study.
About the Authors
A. V. Sudarkina
Novosibirsk State Medical University;
Novosibirsk Railway Clinical Hospital
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
A. P. Dergilev
Novosibirsk State Medical University;
Novosibirsk Railway Clinical Hospital
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
V. V. Kozlov
Novosibirsk State Medical University;
Novosibirsk Regional Oncology Clinic
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
Yu. A. Fokina
Novosibirsk Regional Oncology Clinic
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
I. P. Klimova
Novosibirsk Tuberculosis Research Institute
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
N. A. Gorbunov
Novosibirsk State Medical University
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
K. V. Shalygin
Novosibirsk State Medical University
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
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For citations:
Sudarkina A.V., Dergilev A.P., Kozlov V.V., Fokina Yu.A., Klimova I.P., Gorbunov N.A., Shalygin K.V. DIFFERENTIAL DIAGNOSIS OF MEDIASTINAL LYMPHADENOPATHY IN LYMPHOMA AND SARCOIDOSIS USING DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING. Diagnostic radiology and radiotherapy. 2020;11(3):56-62. (In Russ.) https://doi.org/10.22328/2079-5343-2020-11-3-56-62
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