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Functional changes in neural networks of the brain in patients with spastic diplegia after translingual neurostimulation

https://doi.org/10.22328/2079-5343-2021-12-3-26-34

Abstract

Introduction. Rehabilitation of children with cerebral palsy is one of the most difficult tasks in modern neurology. One of the promising areas is the combination of physiotherapy with methods of stimulation of various parts of the nervous system, among which functional electrical stimulation of muscles and nerves (FES) is distinguished.
Purpose of research. Assessment of changes in the functional connectivity of neural networks in the brain in patients with cerebral palsy before and after translingual neurostimulation using functional MRI at rest.
Materials and methods. Analyzed the results of changes in the functional connectivity of neural networks in the brain in 25 patients with cerebral palsy before and after translingual neurostimulation. A clinical examination was carried out with an assessment of complaints, anamnesis and an assessment on neurological scales, followed by standard and functional MRI of the brain at rest.
Summary. In children with spastic diplegia, functional changes in neural networks with a predominance of processes of strengthening intra- and interhemispheric connections (p<0,05) were revealed, which correlates with clinical changes in the form of a decrease in spasticity and an improvement in motor skills.

About the Authors

D. S. Chegina
Almazov National Medical Research Centre
Russian Federation

 St. Petersburg 



T. S. Ignatova
City Hospital No. 40
Russian Federation

 St. Petersburg 



A. Yu. Efimtsev
Almazov National Medical Research Centre
Russian Federation

 St. Petersburg 



A. S. Lepekhina
Almazov National Medical Research Centre
Russian Federation

 St. Petersburg 



A. G. Levchuk
Almazov National Medical Research Centre
Russian Federation

 St. Petersburg 



G. E. Trufanov
Almazov National Medical Research Centre
Russian Federation

 St. Petersburg 



References

1. Federal clinical guidelines for providing medical care to children with cerebral palsy. Union of Pediatricians of Russia, 2013, 28 р. (In Russ.).

2. Oskoui M., Coutinho F., Dykeman J., Jetté N., Pringsheim T. An update on the prevalence of cerebral palsy: a systematic review and meta-analysis // Dev. Med. Child. Neurol. 2013. Vol. 55, No. 6. Р. 509–519. doi: 10.1111/dmcn.12080.

3. Cerebral palsy. Erin Dean. Nurs. Child Young People. 2017. Vol. 29, No. 3. Р. 11. doi: 10.7748/ncyp.29.3.11. s11.

4. Badalyan L.O. Children’s neurology. Moscow: Publishing house MEDpressinform, 2016. 608 р. (In Russ.).

5. Zvozil A.V., Morenko E.S., Vissarionov S.V., Umnov V.V., Monoshkina T.R., Gerasimenko Y.P., Baindurashvili A.G. Functional and spinal stimulation in complex aftertreatment with cerebral spastic infantile paralysis // Vedical Sciency. 2015. Vol. 2. Р. 40–46.

6. Danilov Y.P., Tyler M.E., Skinner K.L., Hogle R.A., Bach-y-Rita P. Efficacy of electrotactile vestibular substitution in patients with peripheral and central vestibular loss // Journal of Vestibular Research. 2007. Vol. 17, No. 2, 3. Р. 119–113.

7. Danilov Y.P., Tyler M.E., Kaczmarek K.A. Vestibular sensory substitution using tongue electrotactile display. Human Haptic Perception: Basicsand Applications // Birkhauser Basel Switzerland. 2008. Р. 467–480.

8. Ignatova T.S., Scoromets A.R., Kolbin V.E. et al. Translingual brain neurostimulation in treatment of the pediatric cerebral palsy. Bulletin of Rehabilitation Medicine. 2016, Vol. 6, рр. 10–16 (In Russ.).

9. Ignatova T.S., Ikoeva G.A., Kolbin V.E. et al. Evaluation of the effectiveness of translingual neurostimulation in motor rehabilitation in children with spastic diplegia. Pediatric Traumatology, Orthopaedics and Reconstructive Surgery. 2019, Vol. 7, No. 2, рр. 17–24 (In Russ.). doi: 10.17816/PTORS7217-24.

10. Biswal B., Yetkin F.Z., Haughton V.M., Hyde J.S. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI // Magn. Reson. Med. 1995. Vol. 34, No. 4. Р. 537–541. DOI: 10.1002/mrm.1910340409.

11. Qin Y., Li Y., Sun В., Hui He, Peng R., Zhang Т., Li J., Luo Ch., Sun Ch., Yao D. Functional Connectivity Alterations in Children with Spastic and Dyskinetic Cerebral Palsy // Hindawi Neural Plasticity. Vol. 2018. Article ID 7058953. doi: 10.1155/2018/7058953.

12. Qin Y., Sun В., Zhang Н., Li Ya., Zhang Т., Luo Ch., Sun Ch., Yao D. Aberrant Interhemispheric Functional Organization in Children with Dyskinetic Cerebral Palsy // Hindawi Neural Plasticity. Vol. 2019. Article ID 4362539. doi: 10.1155/2019/4362539.

13. Mu X., Wang Zh., Nie В., Duan Sh., Ma Q., Dai G., Wu Ch., Dong Yu., Shan B., Ma L. Altered regional and circuit resting-state activity in patients with occult spastic diplegic cerebral palsy // Pediatrics & Neonatology. 2018. Vol. 59, Issue 4. P. 345–351.

14. Mtuci E., Gruner G., Dockery P. Clinical neuroanatomy and neurology according to Fitzgerald / translated from English / ed. by Yu.A. Shcherbuk, A.Yu. Shcherbuk. Moscow: Panfilov Publishing House, 2018, 400 р. (In Russ.).

15. Lapkin M.M., Trutnev E.A. Selected lectures on normal physiology. Moscow: GEOTAR-Media, 2018, 237 р. (In Russ.).

16. Barkhatova V.P. Neurotransmitter organization and functional significance of the cerebellum. Annals of Clinical and Experimental Neurology, 2010, Vol. 4, No. 3, рр. 44–48 (In Russ.).

17. Sveshnikov A.V. Current data on the structure and function of the cerebellum (Review). Mathematical morphology. 2015. Vol. 14, No. 4 (In Russ.). http://www.smolensk.ru/user/sgma/MMORPH/TITL.HTM.

18. Hill V.B., Cankurtaran C.Z., Liu B.P., Hijaz T.A., Naidich M., Nemeth A.J., Gastala J., Krumpelman C., McComb E.N., Korutz A.W. A Practical Review of Functional MRI Anatomy of the Language and Motor Systems // American Journal of Neuroradiology. 2019. Vol. 40, No. 7. Р. 1084–1090. doi: 10.3174/ajnr.A 6089.

19. Watson C., Kirkcaldie M., Paxinos G. The Brain: An Introduction to Functional Neuroanatomy. Amsterdam: Academic Press, 2010. 171 p.

20. Chouinard P.A., Paus T. The primary motor and premotor areas of the human cerebral cortex // Neuroscientist. 20065. Vol. 12. Р. 143–52. doi: 10.1177/1073858405284255.

21. Stippich C., Naidich T.P.Y., Yousry T.A. Functional neuroanatomy // Stippich C., ed. Clinical Functional MRI: Presurgical Functional Neuroimaging. 2nd ed. Berlin: Springer, 2015. 86 p.

22. Nachev P., Kennard C., Husain M. Functional role of the supplementary and pre-supplementary motor areas // Nat. Rev. Neurosci. 20085. Vol. 9. Р. 856–869. doi: 10.1038/nrn2478.

23. Chung G.H., Han Y.M., Jeong S.H. et al. Functional heterogeneity of the supplementary motor area // AJNR Am. J. Neuroradiol. 2005. Vol. 26. Р. 1819–1823.


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For citations:


Chegina D.S., Ignatova T.S., Efimtsev A.Yu., Lepekhina A.S., Levchuk A.G., Trufanov G.E. Functional changes in neural networks of the brain in patients with spastic diplegia after translingual neurostimulation. Diagnostic radiology and radiotherapy. 2021;12(3):26-34. (In Russ.) https://doi.org/10.22328/2079-5343-2021-12-3-26-34

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