Multivoxel 1H-mr spectroscopy as a potential diagnostic tool in the complex diagnosis of multiple sclerosis type conversion: a case report
https://doi.org/10.22328/2079-5343-2022-13-2-81-84
Abstract
The onset of progressive deficit in multiple sclerosis (MS) was often determined retrospectively with difficulties in diagnostic. This is a case report with subtle MS progression. Clinical and structural MRI anamnesis was complemented with multivoxel 1HMRS examination. The patient complained of the walking distance reducing, gradually increasing spasticity in the distal parts of lower extremities, unsteadiness when walking, clumsy movements. Choline and myoinositol levels were predominantly increased in the area of the cingulate gyrus versus other gray matter regions and the same picture was observed in adjacent white matter. Multivoxel 1H-MRS represents a diagnostic tool that can be very useful in complex diagnostic of MS progression. Measuring chemical-pathological changes diffusely in brain tissues may detect distinctive for progression metabolic patterns.
About the Authors
G. G. Shkilnyuk
N. P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Cand. of Sci. (Med.), neurologist, scientific researcher of the laboratory of neuroimmunology
Akademika Pavlova Street, 9, St. Petersburg, 197376, Russia
A. A. Bogdan
N. P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Cand. of Sci. (Med.), radiologist, junior scientific researcher of the laboratory of stereotacsis
Akademika Pavlova Street, 9, St. Petersburg, 197376, Russia
E. V. Kryukova
N. P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Cand. of Sci. (Med.). scientific researcher of the laboratory of preparation intracerebral delivery
Akademika Pavlova Street, 9, St. Petersburg, 197376, Russia
I. D. Stolyarov
N. P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Dr. of Sci. (Med.), neurologist, head of the laboratory of neuroimmunology
Akademika Pavlova Street, 9, St. Petersburg, 197376, Russia
T. N. Trofimova
N. P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Corresponding Member of the Russian Academy of Sciences, Dr. of Sci. (Med.), professor, radiologist, Institute of the human brain; The main specialist of the laboratory of neuroimaging
Akademika Pavlova Street, 9, St. Petersburg, 197376, Russia
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Review
For citations:
Shkilnyuk G.G., Bogdan A.A., Kryukova E.V., Stolyarov I.D., Trofimova T.N. Multivoxel 1H-mr spectroscopy as a potential diagnostic tool in the complex diagnosis of multiple sclerosis type conversion: a case report. Diagnostic radiology and radiotherapy. 2022;13(2):81-84. https://doi.org/10.22328/2079-5343-2022-13-2-81-84
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