High 11C-methionine uptake in brain abscess: radiological, metabolic and morphological findings: a case report
https://doi.org/10.22328/2079-5343-2022-13-2-85-93
Abstract
An increased amino acid metabolism is characteristic for many brain malignancies. Combined positron emission and computed tomography (PET/CT) with radiolabeled amino acids is often used in recognizing the tumor nature of the structural brain lesion detected on MRI. On 11C-methionine PET/CT a hallmark of a brain tumor is an increased amino acid uptake, topographically coinciding with a structural lesion on MRI. However, high 11C-methionine uptake in the brain lesion is not tumor specific and could be seen in a number of non-tumor diseases. The paper presents three observations of a brain abscess, radiological and metabolic data of which in MRI and 11C-methionine PET/CT simulated a malignant cerebral tumor. The reasons for patients seeking nuclear medicine examination were seizures or focal neurological symptoms, as well as a suspicion of a cerebral tumor based on the contrast-enhanced MRI. Knowledge of the non-tumor disease characterized by high 11C-methionine uptake will help avoid misdiagnosis of a cerebral tumor.
About the Authors
T. Yu. Skvortsova
Federal State Budgetary Institution of Science «The Institute of the Human Brain of N. P. Bekhtereva, the Russian Science Academy
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Leading Researcher of Neuroimaging Laboratory; Chief Scientific Officer of Neuroimaging Laboratory
197376, St. Petersburg, 9, Academician Pavlov St.
zORCID 0000–0003–0598–7576; SPIN-код 6699–3597
Zh. I. Savintseva
Federal State Budgetary Institution of Science «The Institute of the Human Brain of N. P. Bekhtereva, the Russian Science Academy
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Researcher of Neuroimaging Laboratory; Chief Scientific Officer of Neuroimaging Laboratory
197376, St.Petersburg, 9, Academician Pavlov St,
SPIN-код 6620–9449
A. F. Gurchin
Federal State Budgetary Institution of Science «The Institute of the Human Brain of N. P. Bekhtereva, the Russian Science Academy
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Senior Researcher of Neuroimaging Laboratory;, Chief Scientific Officer of Neuroimaging Laboratory
197376, St. Petersburg, 9, Academician Pavlov St,
SPIN-код 9603–0722
B. V. Martynov
Federal State Budgetary Military Institution of Higher Education «the
Military Medical Academy of S. M. Kirov»
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Associate Professor of the Neurosurgery Department
194044, St.Petersburg, 6, Academician Lebedev St
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Review
For citations:
Skvortsova T.Yu., Savintseva Zh.I., Gurchin A.F., Martynov B.V. High 11C-methionine uptake in brain abscess: radiological, metabolic and morphological findings: a case report. Diagnostic radiology and radiotherapy. 2022;13(2):85-93. (In Russ.) https://doi.org/10.22328/2079-5343-2022-13-2-85-93
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