Gestational trophoblastic disease with coexisting progresing pregnancy — pathogenesis, diagnostic strategy, imaging signs: a lecture
E. A. Kirillova,
I. A. Mashchenko,
P. V. Kozlova,
V. S. Egorova,
E. L. Dikareva,
N. A. Osipova,
I. E. Zazerskaya,
E. A. Ulrikh,
G. E. Trufanov https://doi.org/10.22328/2079-5343-2025-16-2-7-19
Abstract
Gestational trophoblastic disease (GTD) is an umbrella term for a group of benign and malignant trophoblastic tumors that develop during or after pregnancy. Despite the fact that trophoblastic tumors are quite rare, they represent an important problem in obstetrics. GTD can result in serious fetal and maternal complications, especially if it is associated with coexisting progressing pregnancy. This lecture covers general concepts related to trophoblastic disease, the role of ultrasound examination and MRI in the primary diagnosis of GTD during developing pregnancy and follow-up monitoring after treatment, as well as sonographic and magnetic resonance signs of this condition.
Keywords
trophoblastic disease,
pregnancy,
diagnostic radiology,
multimodality,
placental magnetic resonance imaging,
placental ultrasonography
Supporting agencies: This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-301).
About the Authors
E. A. Kirillova
Almazov National Medical Research Center
Russian Federation
Russian Federation
Elizaveta A. Kirillova — radiologist, first-year postgraduate student, Department of Radiology and Medical Imaging
2 Akkuratova Street, St. Petersburg 197341
I. A. Mashchenko
Almazov National Medical Research Center
Russian Federation
Russian Federation
Irina A. Mashchenko — Cand. of Sci. (Med.), Associate Professor, Department of Radiology and Medical Imaging
2 Akkuratova Street, St. Petersburg 197341
P. V. Kozlova
Almazov National Medical Research Center
Russian Federation
Russian Federation
Polina V. Kozlova — radiologist, ultrasound examination specialist, educator, Department of Radiology and Medical Imaging
2 Akkuratova Street, St. Petersburg 197341
V. S. Egorova
Almazov National Medical Research Center
Russian Federation
Russian Federation
Veronika S. Egorova — radiologist, Federal State Budgetary
2 Akkuratova Street, St. Petersburg 197341
E. L. Dikareva
Almazov National Medical Research Center
Russian Federation
Russian Federation
Elena L. Dikareva — Cand. of Sci. (Med.), Senior Research Associate, Research Laboratory of Gynecologic Oncology
2 Akkuratova Street, St. Petersburg 197341
N. A. Osipova
Almazov National Medical Research Center
Russian Federation
Russian Federation
Natalia A. Osipova — Dr. of Sci. (Med.), Professor, Department of Obstetrics and Gynecology, Head of Department for the Treatment of Abnormal Pregnancy Conditions
2 Akkuratova Street, St. Petersburg 197341
I. E. Zazerskaya
Almazov National Medical Research Center
Russian Federation
Russian Federation
Irina E. Zazerskaya — Dr. of Sci. (Med.), Professor, Head of Department of Obstetrics and Gynecology
2 Akkuratova Street, St. Petersburg 197341
E. A. Ulrikh
Almazov National Medical Research Center; Petrov National Medical Research Center
Russian Federation
Russian Federation
Elena A. Ulrikh — Dr. of Sci. (Med.), Professor, Head of Research Laboratory of Gynecologic Oncology and Oncofertility; Leading Research Associate
2 Akkuratova Street, St. Petersburg 197341; 68 Leningradskaya Street, Pesochny settlement, St. Petersburg 197758
G. E. Trufanov
Almazov National Medical Research Center
Russian Federation
Russian Federation
Gennadiy E. Trufanov — Dr. of Sci. (Med.), Professor, Principal Research Associate, Department of Research in Diagnostic Radiology, Head of Department of Radiology and Medical Imaging
2 Akkuratova Street, St. Petersburg 197341
References
1. Ulrikh E.A., Dikareva E.L., Zhamborova O.A. et al. Malignant trophoblastic disease: a rare tumor requiring personalized treatment. State-of-the-art. Russian Journal for Personalized Medicine, 2022, Vol. 2, No. 4, pp. 44–55 (In Russ.). doi: 10.18705/2782-3806-2022-2-4-44-55.
2. Mamedli S.N., Chekalova M.A., Meshcheriakova L.A. Modern approaches to the diagnosis of malignant trophoblastic tumors. Journal of Modern Oncology, 2021, Vol. 23, No. 2, pp. 345–348 (In Russ.). doi: 10.26442/18151434.2021.2.200478.
3. Lukinovic N., Malovrh E.P., Takac I. et al. Advances in diagnostics and management of gestational trophoblastic disease // Radiology and Oncology. 2022. Vol. 56, No. 4. Р. 430–439. doi: 10.2478/raon-2022-0038.
4. Chawla T., Bouchard-Fortier G., Turashvili G. et al. Gestational trophoblastic disease: an update // Abdominal Radiology. 2023. Vol. 48, No. 5. P. 1793–1815. doi: 10.1007/s00261-023-03820-5.
5. Ul’rih E.A., Tyulyandina A.S., Procenko S.A. et al. Practical recommendations on drug treatment of malignant trophoblastic tumours. RUSSCO Practice Guidelines, Part 1. Malignant tumours, 2023, Vol. 13, No. 3s2, pp. 280–290 (In Russ.). doi: 10.18027/2224-5057-2023-13-3s2-1-280-290.
6. Das S., Sethy M., Das S.S. et al. Successful Management of Persistent Gestational Trophoblastic Neoplasia: A Comprehensive Review and Case Analysis // Cureus. 2023. Vol. 15, No. 12: e51112. doi: 10.7759/cureus.51112.
7. Lin L.H., Maestá I., Braga A. et al. Multiple pregnancies with complete mole and coexisting normal fetus in North and South America: A retrospective multicenter cohort and literature review // Gynecologic Oncology. 2017. Vol. 145, No. 1. Р. 88–95. doi: 10.1016/j.ygyno.2017.01.021.
8. Cavoretto P., Cioffi R., Mangili G. et al. A Pictorial Ultrasound Essay of Gestational Trophoblastic Disease // Journal of Ultrasound in Medicine. 2020. Vol. 39, No. 3. Р. 597–613. doi: 10.1002/jum.15119.
9. Ning F., Hou H., Morse A.N. et al. Understanding and management of gestational trophoblastic disease. // F1000Research. 2019. Vol. 8, F1000 Faculty Rev-428. doi:10.12688/f1000research.14953.1.
10. Fadl S. A., Linnau K. F., Dighe M. K. Placental abruption and hemorrhage—review of imaging appearance // Emergency Radiology. 2019. Vol. 26, No. 1. Р. 87–97. doi: 10.1007/s10140-018-1638-3.
11. Imafuku H., Miyahara Y., Ebina Y., Yamada H. Ultrasound and MRI Findings of Twin Pregnancies with Complete Hydatidiform Mole and Coexisting Normal Fetus: Two Case Reports // The Kobe Journal оf Medical Sciences. 2018. Vol. 64, No. 1. Р. E1-E5.
12. Swamy S.R., Swamy M.R., Samanvitha H. MR«I»: An «eye» for the preoperative diagnosis of ectopic molar pregnancy, a case report // Journal of Family Medicine and Primary Care. 2023. Vol. 12, No. 3. Р. 581–585. doi: 10.4103/jfmpc.jfmpc177022.
13. Liu Y., Tong A., Qi X. A large subchorionic hematoma in pregnancy: A case report // Medicine (United States). 2020. Vol. 99, No. 22. Р. e20280. doi: 10.1097/MD.0000000000020280.
14. Ballah D., Mawad K., Gandhi S. et al. More Than Just a Mole: Multimodality Imaging of Placental Masses and Mimickers // European Congress of Radiology (Vien). 2016. March 02–06. Poster number C-1682. doi: 10.1594/ecr2016/C-1682.
15. Lamrissi A., Mabengui A.F., Mourabbih M. et al. Acquired uterine arterio-venous malformation post molar pregnancy suction-curettage: 2 case reports // International Journal of Surgery Case Reports. 2022. Vol. 94. doi: 10.1016/j.ijscr.2022.107105.
Review
For citations:
Kirillova E.A., Mashchenko I.A., Kozlova P.V., Egorova V.S., Dikareva E.L., Osipova N.A., Zazerskaya I.E., Ulrikh E.A., Trufanov G.E. Gestational trophoblastic disease with coexisting progresing pregnancy — pathogenesis, diagnostic strategy, imaging signs: a lecture. Diagnostic radiology and radiotherapy. 2025;16(2):7-19. (In Russ.) https://doi.org/10.22328/2079-5343-2025-16-2-7-19
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