82SR/82RB-GENERATOR AND PERSPECTIVES FOR ITS USE IN NEUROONCOLOGY

The paper presents a ⁸²Sr/⁸²Rb-generator and shows the possibility and perspectives to use the radiopharmaceutical (RFP) «Rubidium chloride, from 82Rb generator» (hereinafter referred to as «⁸²Rb-chloride») for the diagnosis of brain tumors (GM) based on the experience of the use of the radiopharmaceutical in the FGBI «RRCRST» of the Ministry of Healthcare of Russia. Results of observation of 23 patients are presented with malignant and benign tumors, and non-neoplastic lesions in the brain. The tendency was detected for the prevalence of increased accumulation of ⁸²Rb-chloride in malignant tumors as compared to benign tumors and in arteriovenous malformations (AVM) in which the 82Rb-chloride is accumulated within the vascular phase, but it is not retained. Ultra-short half-life of the radionuclide [⁸²Rb] (76 sec) and low radiation exposure arising when the 82Rb-chloride is intravenously injected, create completely new possibility for sequential use of two or more radiopharmaceuticals at examining a patient. For example, PET imaging with ¹⁸F-FDG, ¹¹C-L-methionine or ¹¹C-choline can be performed in 7 minutes after the injection of the 82Rb-chloride to a patient. The efficiency of using ⁸²Rb-chloride as a diagnostic tool in the neurooncological patients is stated. The method was develop for dosing and injection of the radiopharmaceutical from a generator. Using a single generator of Rubidium-82 it is possible to run about 800 PET studies. Generator is reliable and easy in use.

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