Preview

Diagnostic radiology and radiotherapy

Advanced search

THE CHANGES IN THE PERIVENTRICULAR ZONE AND BRAIN CORTEX IN PRETERM NEWBORN WITH VERY LOW BIRTH WEIGHT AND EXTREME LOW BIRTH WEIGHT

https://doi.org/10.22328/2079-5343-2017-4-25-32

Abstract

The results of autopsy material of preterm newborns very low birth weight (VLBW) and extremely low birth weight (ELBW) brains are presented. In life the brains lesions were detected in the examined newborns with cranial ultrasound and MRI (intraventricular herminal hemorrhages/IVH and hypoxic — ischemic encephalopathy /HIE). In this researching were been using method of microscopy. Postmortem examination confirmed brain cell migration continues after birth in all examined newborns. This study have detailed the directions, positions, thickness cells migration columns. There were found that cells migration thickness and length depend on gestation age of preterm newborn with IVH and HIE. Besides we found the age morphologic differences in cell structures cerebral cortex in preterm newborns. 

About the Authors

T. V. Melashenko
St. Petersburg State Pediatric Medical University
Russian Federation


T. A. Narkevich
St. Petersburg State Pediatric Medical University
Russian Federation


O. L. Krasnogorskaya
St. Petersburg State Pediatric Medical University
Russian Federation


A. V. Pozdnykov
St. Petersburg State Pediatric Medical University
Russian Federation


R. A. Nasyrov
St. Petersburg State Pediatric Medical University
Russian Federation


D. O. Ivanov
St. Petersburg State Pediatric Medical University
Russian Federation


References

1. Bell J.B., Becher J.C., Wyatt B. et al. Brain dаmage and axonal injury in a Scottish cohort of neonatal death. Brain, 2005, Vol. 128, рр. 1070–1081.

2. Zontán Molnár and Mary Rutherford. Brain maturation After Preterm Birth, www.Science Translational Medicine.org, 2013, 16 January, Vol S, Iss. 168, 168 ps 2.

3. Gressens P. Mechanisms and disturbances of neuronal migration. Ped. Res., 2000, Vol. 48, рр. 725–730.

4. McClendon E., Chen K., Sharifnia E. et al. Prenatal cerebral ischemia triggers dysmaturation of caudate projection neurons. Ann. Neurol. 2014. Vol. 75, рр. 508–524.

5. Kostovic I., Kostovic-Srzentic M., Benjak V. et al. Developmental dynamics of radial vulnerability in the cerebral compartments in preterm infants and neonates. Front. Neurol., 2014, 29 July. https://doi.org/10.3389/fneur.2014.00139.

6. Ball G., Boardman J.P., Rueckert D. et al. The effect of preterm birth on thalamic and cortical development. Cereb. Cortex, 2012, Vol. 22, рр. 1016–1024.

7. Salmaso N., Tomasi S., Vaccarino F.M. Neurogenesis and maturation in neonatal brain injury. Clin. Perinatol., 2014, Vol. 41 (1), рр. 229–239.

8. Matsumato J.A., Goskin C.M., Kreitel K.D., Kahn S.L. MRI Atlas of Pediatric Brain Maturation and Anatomy. Oxford University Press, 2015, рр. 1–505. ISBN 978-0-19-979642-7.

9. Проценко Л.П., Перетятко Л.П., Васильева М.Е. Особенности экспрессии ммр-9 в структурах головного мозга плодов и новорожденных 22–40 недель гестации при вентрикуломегалии и гидроцефалии // Детская медицина Северо-Запада. 2012. Т. 3, № 2. C. 32–34. [Procenko L.P., Peretyatko L.P., Vasil’eva M.E. Osobennosti ehkspressii mmr-9 v strukturah golovnogo mozga plodov i novorozhdennyh 22–40 nedel’ gestacii pri ventrikulomegalii i gidrocefalii, Detskaya medicina Severo-Zapada, 2012, Vol. 3, No 2, рр. 32–34. (In Russ.)].

10. Lui J. H., Hansen D.V., Kriegstein A.R. Development and evolution of the human neocortex. Cell, 2011, Vol. 146, рр. 18–36.

11. Indredavok M.S., Vik T. et al. Perinatal risk and psychiatric outcome in adolescents born preterm with very low birth weight or term small for gestational age. J. dev Behav Pediatr., 2010, Vol. 31 (4), рр. 286–294.

12. Raets M., Dudink J. et al. Brain vein disorders in newborn infants. Dev. Medicine & Child Neurology, 2015, Vol. 57, рр. 229–240.

13. Перетятко Л.П., Кулида Л.В., Проценко Е.В. Морфология плодов и новорожденных с экстремально низкой массой тела. Иваново: ОАО «Издательство Иваново», 2005. 384 с. [Peretyatko L.P., Kulida L.V., Procenko E.V. Morfologiya plodov i novorozhdennyh s ehkstremal’no nizkoj massoj tela. Ivanovo: OAO «Izdatel’stvo Ivanovo», 2005. 384 р. (In Russ.)].

14. Volpe J.J. Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol., 2009, Vol. 8 (1), рр. 110–124.


Review

For citations:


Melashenko T.V., Narkevich T.A., Krasnogorskaya O.L., Pozdnykov A.V., Nasyrov R.A., Ivanov D.O. THE CHANGES IN THE PERIVENTRICULAR ZONE AND BRAIN CORTEX IN PRETERM NEWBORN WITH VERY LOW BIRTH WEIGHT AND EXTREME LOW BIRTH WEIGHT. Diagnostic radiology and radiotherapy. 2017;(4):25-32. (In Russ.) https://doi.org/10.22328/2079-5343-2017-4-25-32

Views: 4286


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2079-5343 (Print)