Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) new radiological features: a case report
https://doi.org/10.22328/2079-5343-2022-13-3-88-96
Abstract
A new form of morphologically and molecularly distinguishable epileptogenic neoplasia with characteristic microscopic findings and a distinct DNA methylation signature as well as frequent genetic anomalies, was revealed in 2017; the tumor was called polymorphous low-grade neuroepithelial tumor of the young (PLNTY). Several specific radiological patterns found in PLNTY when compared with the results of a pathomorphological study being useful in differential diagnosis with other epileptogenic tumors were mentioned in certain papers. Our paper is devoted to some particulars of the radiological picture in two children with pharmacoresistant epilepsy who underwent epileptic surgery with histological verification of PLNTY.
About the Authors
V. S. Khalilov
Federal Research and Clinical Center for Children and Adolescents; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Varis S. Khalilov — Dr. of Sci. (Med.), Associate professor at the Department of Neurology, Neurosurgery and Medical Genetics named after academician L.O.Badalyan, Faculty of Pediatrics; Radiologist of the MRI Department, FR CCC A FMBA of Russia,
Moscow, Ostrovitjanova str. 1; Moscow, Moskvorechye str. 20
A. N. Kislyakov
Morozov Children Clinical Hospital
Russian Federation
Russian Federation
Alexey N. Kislyakov — Head of the Pathology Department, Morozov Children City Hospital
119049, 4th Dobryninskiy pereulok, 1/9, Moscow
N. A. Medvedeva
Federal Research and Clinical Center for Children and Adolescents
Russian Federation
Russian Federation
Natalia A. Medvedeva — radiologist of the MRI Department.
Moscow, Moskvorechye str. 20
A. V. Sadykova
Federal Research and Clinical Center for Children and Adolescents
Russian Federation
Russian Federation
Anna V. Sadykova — Dr. of Sci. (Med.), Head of the Department of Neurology.
Moscow, Moskvorechye str. 20
D. N. Kopachev
Scientific Center of Neurology
Russian Federation
Russian Federation
Dmitry N. Kopachev — Dr. of Sci. (Med.), neurosurgeon at the Department of Neurosurgery.
Moscow
А. A. Kholin
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Alexey A. Kholin — Dr. of Sci. (Med.), Professor at the Department of Neurology, Neurosurgery and Medical Genetics named after academician L.O.Badalyan, Faculty of Pediatrics.
Moscow, Ostrovitjanova str. 1
References
1. Slegers R.J., Blumcke I. Low-grade developmental and epilepsy associated brain tumors: a critical update 2020 // Acta Neuropathol. Commun. 2020. Vol. 8, No. 1. Р. 27. Р. 1–11 doi: 10.1186/s40478-020-00904-x. PMID: 32151273; PMCID: PMC7063704.
2. Huse J.T., Snuderl M., Jones D.T., Brathwaite C.D., Altman N. et al. Polymorphous Low-Grade Neuroepithelial Tumor of the Young (PLNTY): An Epileptogenic Neoplasm With Oligodendroglioma-Like Components, Aberrant CD34 Expression, and Genetic Alterations Involving the MAP Kinase Pathway // Acta Neuropathol. 2017. Vol. 133, No. 3. Р. 417–429. doi: 10.1007/s00401-016-1639-9.
3. Benson J.C., Summerfield D., Carr C., Cogswell P., Messina S. et al. Polymorphous Low-Grade Neuroepithelial Tumor of the Young as a Partially Calcified IntraAxial Mass in an Adult // AJNR Am. J. Neuroradiol. 2020. Vol. 41, No. 4. Р. 573–578. doi: 10.3174/ajnr.A6500.
4. Samura K., Morioka T., Yoshida F., Hashiguchi K., Miyagi Y. et al. Focal cortical dysplasia with calcification: a case report // Childs Nerv. Syst. 2008. Vol. 24. Р. 619– 622. doi: 10.1007/s00381-007-0566-4.
5. Broggi G., Certo F., Altieri R., Caltabiano R., Gessi M. et al. A «polymorphous low-grade neuroepithelial tumor of the young (PLNTY)» diagnosed in an adult. Report of a case and review of the literature // Surg. Neurol. Int. 2021. Vol. 12. 470. Р. 1–7. doi: 10.25259/SNI_500_2021.
6. Fei X., Zhao J., Wei W., Wang W., Kong X. et al. Clinical, Radiological, Pathological Features and Seizure Outcome With Surgical Management of Polymorphous Low-Grade Neuroepithelial Tumor of the Young Associated With Epilepsy // Front. Oncol. 2022. Vol. 12. 863373. Р. 1–9. doi: 10.3389/fonc.2022.863373.
7. Kholin A.A., Khalilov V.S., Vasil’ev I.G., Il’ina E.S., Zavadenko N.N. Treatment of epilepsy in children with brain tumors // Zhurnal Nevrologii i Psikhiatrii imeni S.S.Korsakova. 2016. Vol. 116, No. 9=2. Р. 37–43 (In Russ.). https://doi.org/10.17116/jnevro20161169237-43.
8. Bitar M., Danish S.F., Rosenblum M.K. A Newly Diagnosed Case of Polymorphous Low-Grade Neuroepithelial Tumor of the Young // Clin. Neuropathol. 2018. Vol. 37, No. 4. Р. 178–181. doi: 10.5414/NP301081.
9. Johnson D.R., Giannini C., Jenkins R.B., Kim D.K., Kaufmann T.J. Plenty of Calcification: Imaging Characterization of Polymorphous Low-Grade Neuroepithelial Tumor of the Young // Neuroradiology. 2019. Vol. 61, No. 11. Р. 1327–1332. doi: 10.1007/s00234-019-02269-y.
10. Kurokawa M., Kurokawa R., Capizzano A.A., Akira B., Yoshiaki O. et al. Neuroradiological features of the polymorphous low-grade neuroepithelial tumor of the young: five new cases with a systematic review of the literature // Neuroradiology. 2022. Vol. 64. Р. 1255–1264. https://doi.org/10.1007/s00234-021-02879-5.
11. Chen Y., Tian T., Guo X., Zhang F., Fan М. et al. Polymorphous low-grade neuroepithelial tumor of the young: case report and review focus on the radiological features and genetic alterations // BMC Neurol. 2020. Vol. 20, No. 123. Р. 1–7. https://doi.org/10.1186/s12883-020-01679-3.
12. Khalilov V.S., Kholin A.A., Kisyakov A.N., Medvedeva N.A., Bakaeva B.R. Neuroradiological and pathomorphological features of epilepsy associated brain tumors // Diagnostic radiology and radiotherapy. 2021. Vol. 12, No. 2. P. 7–21. http://dx.doi.org/10.22328/2079-5343-2021-12-2-7-21.
13. Tateishi K., Ikegaya N., Udaka N., Sasame J., Hayashi T. et al. BRAF V600E mutation mediates FDG-methionine uptake mismatch in polymorphous low-grade neuroepithelial tumor of the young // Аcta Neuropathol. Commun. 2020. Vol. 8, No. 139. Р. 1–8. https://doi.org/10.1186/s40478-020-01023-3.
Review
For citations:
Khalilov V.S., Kislyakov A.N., Medvedeva N.A., Sadykova A.V., Kopachev D.N., Kholin А.A. Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) new radiological features: a case report. Diagnostic radiology and radiotherapy. 2022;13(3):88-96. https://doi.org/10.22328/2079-5343-2022-13-3-88-96
Views:
1408
Email this article 