Clinical case of pulmonary alveolar proteinosis in a newborn
https://doi.org/10.22328/2079-5343-2024-15-1-111-115
Abstract
Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the accumulation of protein-lipid complexes in the alveoli due to impaired utilization of surfactant by alveolar macrophages; it is most often idiopathic and occurs in healthy men and women aged 30–50 years. The congenital form of PAP is extremely rare, its diagnosis is complicated by the fact that it is impossible to conduct functional lung tests in newborns, and lung biopsy is used extremely rarely. Against this background, data obtained by computed tomography (CT) of the lungs of newborns are of particular importance. The article presents a clinical case of treatment of a newborn with respiratory failure (RF) and signs of pulmonary hypertension, who was admitted to the neonatal intensive care unit of the Children’s City Multidisciplinary Clinical Specialized Center for High Medical Technologies at the age of the first day of life. The article reflects the role of computed tomography in diagnosing the causes of respiratory failure in newborns, as well as the importance of anamnesis and a thorough clinical examination of patients. The presented clinical case demonstrates the need for a multidisciplinary approach to the diagnosis of newborns with pulmonary alveolar proteinosis.
About the Authors
S. V. Starevskaya
St. Petersburg children’s municipal multi-specialty clinical center of high medical technology; St. Petersburg Research Institute of Phthisiopulmonology
Russian Federation
Russian Federation
Svetlana V. Starevskaya — Dr. of Sci. (Med.), Leading Researcher; Associate Professor of Paediatrics and Paediatric Cardiology Department
193036, Ligovsky prospect 2–4, St. Petersburg
191015, Kirochnaya street, 41, St. Petersburg
N. A. Ilyina
St. Petersburg children’s municipal multi-specialty clinical center of high medical technology; North-Western State Medical University named after I.I.Mechnikov
Russian Federation
Russian Federation
Natalia A. Ilyina — Dr. of Sci. (Med.), Professor of Radiology Department
191015, Kirochnaya street, 41, St. Petersburg
198205, Avangardnaya street, 14, St. Petersburg
K. V. Prusakova
North-Western State Medical University named after I.I.Mechnikov
Russian Federation
Russian Federation
Ksenya V. Prusakova — Radiologist of the Department of Diagnostic Radiology
198205, Avangardnaya street, 14, St. Petersburg
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Review
For citations:
Starevskaya S.V., Ilyina N.A., Prusakova K.V. Clinical case of pulmonary alveolar proteinosis in a newborn. Diagnostic radiology and radiotherapy. 2024;15(1):111-115. (In Russ.) https://doi.org/10.22328/2079-5343-2024-15-1-111-115
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