CLINICAL AND RADIOLOGICAL EVALUATION OF POSTPERFUSIONAL PULMONARY EDEMA AS AN ISOLATED LUNG CHEMOPERFUSION COMPLICATION

The aim of this study was to estimate possibilities of CT and radiography in the diagnosis postperfusional pulmonary edema (PPE). Postperfusional pulmonary edema is the complication of normothermic isolated lung chemoperfusion (ILCP). In our clinic 74 patients with isolated lung metastases underwent 101 ILCP Postperfusional pulmonary edema was diagnosed in 31 (30,7%). In 9 (29%) cases PPE was manifested in the form of interstitial pulmonary edema, in 19 (61,3%) cases in form of mixed pulmonary edema and in 3 (9,7%) cases in form alveolar pulmonary edema. The study determined correlation between clinical and radiological manifestations of PPE and PPE diagnostic algorithm was developed.

компьютерная томография, рентгенография, метастатическое поражение легких, изолированная химиоперфузия легкого, цисплатин, мелфалан, CT, radiography, lung metastases, isolated lung perfusion, cisplatin, melphalan

1. Трахтенберг А. Х., Паршин В. Д., Пикин О. В. и др. Хирургическое лечение метастазов колоректального рака в легких // Росс. онкол. журнал.- 2005.- № 4.- С. 18-21.

2. Чиссов В. И., Трахтенберг А. Х., Пикин О. В. Метастатические опухоли легких.- М.: ГЭОТАР-Медиа, 2009.- 160 с.

3. Hendriks J. М., Grootenboers M. J., Schramel F. М. et al. Isolated lung perfusion with melphalan for resectable lung metastases: a phase I clinical trial // Ann. Thorac. Surg.- 2004.- Vol. 78.- P 1919-1926.

4. Pastorino U., Buyse М., Friedel G. et al. Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases // J. Thorac. Cardiovasc. Surg.- 1997.- Vol. 113.- P 37-49.

5. Van Schil P. E. Surgical treatment for pulmonary metastases // Acta. Clin. Belg.- 2002.- Vol. 57.- P. 333-339.

6. Van Schil P. E., Hendriks J. М., Van Putte B. Р Isolated lung perfusion and related techniques for the treatment of pulmonary metastases // J. Cardiothorac. Surg.- 2008.- Vol. 33.- P. 487-496.

7. Blackmon S. H., Stephens E. H., Correa A. M. et al. Predictors of recurrent pulmonary metastases and survival after pulmonary metastasectomy for colorectal cancer // Ann. Thorac. Surg.- 2012.- Vol. 6 (94).- P 1802-1809.

8. Hendriks J. M., Van Putte B. P., Grootenboers M. et al. Isolated lung perfusion for pulmonary metastases // Thorac. Surg. Clin.- 2006.- Vol. 16.- P. 185-198.

9. Takakura Y., Miyata Y., Okajima M. et al. Short disease-free interval is a significant risk factor for intrapulmonary recurrence after resection of pulmonary metastases in colorectal cancer // Colorectal Dis.- 2010.- Vol. 12.- P. 68-57.

10. Hendriks J. М., Romijn S., Van Putte B. et al. Long-term results of surgical resection of lung metastases // Acta. Chir. Belg.- 2001.- Vol. 101.- P. 267-272.

11. Hengst W. A., Hendriks J. М., Balduyck B. et al. Phase II Multicenter Clinical Trial of Pulmonary Metastasectomy and Isolated Lung Perfusion with Melphalan in Patients with Resectable Lung Metastases // Journal of Thoracic Oncology.- 2014.- Vol. 9.- P. 1547-553.

12. Ratto G. B., Toma S., Civalleri D. et al. Isolated lung perfusion with platinum in the treatment of pulmonary metastases from soft tissue sarcomas // J. Thorac. Cardiovasc. Surg.- 1996.- Vol. 112.- P. 614-622.

13. Ward A., Prokrym K., Pass H. Isolated Lung Perfusion for Pulmonary Metastases // Thoracic. Surgery Clinics.- 2016.- Vol. 26 (1).- P. 55-67.

14. Grootenboers M. J., Schramel F. M., Boven W. J. et al. Re-evaluation of toxicity and long-term follow-up of isolated lung perfusion with melphalan in patients with resectable pulmonary metastases: phase I and extentional trial // Ann. Thorac. Surg.- 2007.- Vol. 83.- P. 1235-1236.

15. Авдеев С. Н. Дыхательная недостаточность // Consilium Medicum.- 2004.- № 4.- С. 44-48.

16. Гиппи М. А. Патофизиология легких.- СПб.: Невский диалект, 1999.- 344 с.

17. Левченко Е. В., Сенчик К. Ю., Барчук А. С. и др. Изолированная химиоперфузия легкого по поводу метастазов солидных опухолей // Онкохирургия.- 2012.- Т. 4.- С. 46-53.