BRAIN AND SPINE ATROPHY IN RELAPSING REMITTING MULTIPLE SCLEROSIS: A 3-YEAR FOLLOWUP STUDY
https://doi.org/10.22328/2079-5343-2017-1-35-39
Abstract
Nowadays neurodegeneration in multiple sclerosis is closely associated with irreversible disability progression. However, the involvement sequence of different regions in atrophy is still unclear. The aim of our study was to determine the relationship between brain and spine atrophy and neurological disability in relapsing-remitting multiple sclerosis (RRMS) patients. 45 RRMS patients underwent brain and spine MRI with voxel based morphometry and neurological examination with EDSS and were compared to 20 healthy controls. As a result we determined a distinct patterns of atrophy distribution in MS patients and the sequence of involvement of different central nervous system regions. A strong correlation between disability progression rate and gray matter atrophy rate was detected.
About the Authors
I. A. Krotenkova
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
V. V. Bryukhov
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
M. N. Zakharova
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
S. N. Morozova
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
M. V. Krotenkova
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
L. Sh. Askarova
Research Center of Neurology
Russian Federation
Russian Federation
Moscow
References
1. Miller D. H., Barkhof F., Frank J. A., Parker G. J. M., Thompson A. J., Brain, 2002, vol. 125, Pt 8, рр. 1676–1695.
2. Krotenkova M. V., Kugoev A. I., Konovalov R. N., Trifanova V. A., Zavalishin I. A., Peresedova A. V., Medicinskaya vizualizaciya, 2001, No. 1, рр. 62–66.
3. Bryuhov V. V., Kulikova S. N., Krotenkova M. V., Peresedova A. V., Zavalishin I. A., Annaly klinicheskoj i eksperimentalnoj nevrologii, 2013, No. 3, рр. 47–53.
4. Yudina E. N., Konovalov R. N., Abramycheva N. Yu., Klyushnikov S. A., Illarioshkin S. N., Ann. klinicheskoj i eksperimentalnoj nevrologii, 2013, vol. 7, No. 4, рр. 16–19.
5. Vollmer T., Signorovitch J., Huynh L., J. Neurol. Sci., 2015, vol. 357, No. 1, рр. 8–18.
6. Paul F., Acta Neurol. Scand., 2016, vol. 134, рр. 24–33.
7. Steenwijk M. D., Geurts J. J. G., Daams M., Tijms B. M., Wink A. M., Balk L. J., Tewarie P. K., Uitdehaag B. M. J., Barkhof F., Vrenken H., Pouwels P. J. W., Brain, 2016, vol. 139, No. 1, рр. 115–126.
8. Riley C., Azevedo C., Bailey M., Pelletier D., Expert Rev. Neurother, 2012, vol. 12, No. 3, рр. 323–333.
9. Prahova L. N., Bogdan A. A., Ilves A. G., Magonov E. P., Savinceva Zh. I., Trofimova T. N., Luchevaya diagnostika i terapiya, 2015, No. 4, рр. 35–41.
10. Deppe M., Krämer J., Tenberge J. G., Marinell J., Schwindt W., Deppe K., Groppa S., Wiendl H., Meuth S. G., Hum. Brain Mapp., 2016, vol. 37, No. 5, рр. 1866–1879.
11. Bermel R. A., Bakshi R., Lancet Neurol., 2006, vol. 5, No. 2, рр. 158–170.
12. Oreja-Guevara C., Rovaris M., Iannucci G., Valsasina P., Caputo D., Cavarretta R., Sormani M.P., Ferrante P., Comi G., Filippi M., Arch. Neurol., 2005, vol. 62, No. 4, рр. 578–584.
13. Barkhof F., Simon J. H., Fazekas F., Rovaris M., Kappos L., Stefano N., Polman C. H., Petkau J., Radue E. W., Sormani M. P., D. Li K., O’Connor P., Montalban X., Miller D. H., Filippi M., Nat. Rev. Neurol., 2012, vol. 8, No. 1, рр. 13–21.
Review
For citations:
Krotenkova I.A., Bryukhov V.V., Zakharova M.N., Morozova S.N., Krotenkova M.V., Askarova L.Sh. BRAIN AND SPINE ATROPHY IN RELAPSING REMITTING MULTIPLE SCLEROSIS: A 3-YEAR FOLLOWUP STUDY. Diagnostic radiology and radiotherapy. 2017;(1):35-39. (In Russ.) https://doi.org/10.22328/2079-5343-2017-1-35-39
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