ARTERIAL INFUSION AND RADIOTHERAPY IN PATIENTS WITH LOCALLYADVANCED PANCREATIC CANCER
https://doi.org/10.22328/2079-5343-2017-1-88-93
Abstract
We evaluated the combination of celiac axis infusion Gemcitabine 1000 mg/m2 with Oxaliplatin 75 mg/m2 and 3D conformal radiotherapy (51 Gy in 17 fractions over 3 weeks) in 3 patients with locally advanced pancreatic cancer. In case 1, a high survival rate (14 mo) was achieved in patients with locally advanced tumor body of the pancreas and metastases in the regional lymph nodes. The patient 2 had pancreatic cancer with metastatic lesions of the liver and malignant obstructive jaundice; the latter was successfully controlled by biliary stenting. The following combined treatment was uncomplicated and survival was 13 mo. In case 3, the pain syndrome dramatically decreased and the patient is still alive for 14 mo from the start of combination therapy. It is concluded that combination of arterial infusion and radiotherapy is safe and promising treatment for patients with locally advanced pancreatic cancer.
About the Authors
A. V. Kozlov
Russian Scientific Center of Radiology and Surgical Technologies
Russian Federation
Russian Federation
St. Petersburg
P. G. Tarazov
Russian Scientific Center of Radiology and Surgical Technologies
Russian Federation
Russian Federation
St. Petersburg
A. V. Pavlovskij
Russian Scientific Center of Radiology and Surgical Technologies
Russian Federation
Russian Federation
St. Petersburg
L. I. Korytova
Russian Scientific Center of Radiology and Surgical Technologies
Russian Federation
Russian Federation
St. Petersburg
E. V. Rozengauz
Russian Scientific Center of Radiology and Surgical Technologies
Russian Federation
Russian Federation
St. Petersburg
E. V. Vlasova
Russian Scientific Center of Radiology and Surgical Technologies
Russian Federation
Russian Federation
St. Petersburg
M. S. Tlostanova
Russian Scientific Center of Radiology and Surgical Technologies
Russian Federation
Russian Federation
St. Petersburg
References
1. Kohanenko N. Yu., Amosov V. I., Ignashov A. M., Gladinova T. S., Volkov O. N., Ignateva I. A., Yakovleva E. S., Osipenko S. K., Savrasov V. M., Tabidze I. B., Sopiya E. R., Voprosy onkologii, 2001, vol. 47, No. 3, рр. 343–347.
2. Wenz F., Tiefenbacher U., Fuss M., Lohr F., Pancreatology, 2003, vol. 3, No. 5, рр. 359–365.
3. Yokoyama Y., Nimura Y., Nagino M., Surg. Today, 2009, vol. 39, No. 6, рр. 466–475.
4. Ducreux M., Giovannini M., Baey C., Llacer C., Bennouna J., Adenis A., Peiffert D., Mornex F., Abbas M., Boige V., Pignon J. P., Conroy T., Cellier P., Juzyna B., Viret F., Dig. Liver Dis, 2014, vol. 46, No. 10, рр. 950–955.
5. Intervencionnaya radiologiya v onkologii, pod red. A. M. Granova, M. I. Davydova, St. Petersburg: Foliant, 2013, 560 р.
6. Liu X., Chen J., Yao W., Zhonghua Zhong Liu Za Zhi, 1999, vol. 21, No. 5, рр. 369–370. (in Chinese with English abstract).
7. Tanaka T., Sakaguchi H., Anai H., Yamamoto K., Morimoto K., Tamamoto T., Kichikawa K., Am. J. Roentgenol., 2007, vol. 189, No. 2, рр. 421–428.
8. Tanaka T., Nishiofuku H., Tamamoto T., Sho M., Anai H., Sueyoshi S., Sakaguchi H., Hasegawa M., Nakajima Y., Kichikawa K., Anticancer Res, 2011, vol. 31, No. 11, рр. 3909–3912.
9. Liu F., Tang Y., Sun J. et al., PLoS One, 2012, vol. 7, No. 7, e40847 [PMID: 22815840 DOI: 0.1371/journal.pone.0040847].
10. Davis J. L., Pandalai P. K., Ripley R. T., Langan R. S., Avital I., Pancreas, 2012, vol. 41, No. 5, рр. 678–684.
11. Han G. H., Yin Z. H., Meng X. J., He C. Y., Zhang H. V., Sun A. H., Wu K. S., Ding J., Fan D. M., Chin. J. Dig. Dis., 2006, vol. 7, рр. 45–48.
Review
For citations:
Kozlov A.V., Tarazov P.G., Pavlovskij A.V., Korytova L.I., Rozengauz E.V., Vlasova E.V., Tlostanova M.S. ARTERIAL INFUSION AND RADIOTHERAPY IN PATIENTS WITH LOCALLYADVANCED PANCREATIC CANCER. Diagnostic radiology and radiotherapy. 2017;(1):88-93. (In Russ.) https://doi.org/10.22328/2079-5343-2017-1-88-93
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